High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Maria F Lopes-Virella, Nathaniel L Baker, Kelly J Hunt, Timothy J Lyons, Alicia J Jenkins, Gabriel Virella, DCCT/EDIC Study Group

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.
Original languageEnglish
Pages (from-to)1333-40
Number of pages8
JournalDiabetes Care
Volume35
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Adult
  • Albuminuria
  • Biological Markers
  • Cholesterol, LDL
  • Diabetes Mellitus, Type 1
  • Diabetic Retinopathy
  • Disease Progression
  • Female
  • Glycosylation End Products, Advanced
  • Hemoglobin A, Glycosylated
  • Humans
  • Lipoproteins, LDL
  • Male
  • Proportional Hazards Models
  • Risk Factors

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