High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Maria F Lopes-Virella; Nathaniel L Baker; Kelly J Hunt; Timothy J Lyons; Alicia J Jenkins; Gabriel Virella; DCCT/EDIC Study Group

doi:10.2337/dc11-2040

High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Maria F Lopes-Virella, Nathaniel L Baker, Kelly J Hunt, Timothy J Lyons, Alicia J Jenkins, Gabriel Virella, DCCT/EDIC Study Group

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.

Original language	English
Pages (from-to)	1333-40
Number of pages	8
Journal	Diabetes Care
Volume	35
Issue number	6
DOIs	https://doi.org/10.2337/dc11-2040
Publication status	Published - Jun 2012

Keywords

Adult
Albuminuria
Biological Markers
Cholesterol, LDL
Diabetes Mellitus, Type 1
Diabetic Retinopathy
Disease Progression
Female
Glycosylation End Products, Advanced
Hemoglobin A, Glycosylated
Humans
Lipoproteins, LDL
Male
Proportional Hazards Models
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc11-2040

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@article{a646437c08b04f74aa4827646804964a,

title = "High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes",

abstract = "To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.",

keywords = "Adult, Albuminuria, Biological Markers, Cholesterol, LDL, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Disease Progression, Female, Glycosylation End Products, Advanced, Hemoglobin A, Glycosylated, Humans, Lipoproteins, LDL, Male, Proportional Hazards Models, Risk Factors",

author = "Lopes-Virella, {Maria F} and Baker, {Nathaniel L} and Hunt, {Kelly J} and Lyons, {Timothy J} and Jenkins, {Alicia J} and Gabriel Virella and {DCCT/EDIC Study Group}",

year = "2012",

month = jun,

doi = "10.2337/dc11-2040",

language = "English",

volume = "35",

pages = "1333--40",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "6",

}

TY - JOUR

T1 - High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

AU - Lopes-Virella, Maria F

AU - Baker, Nathaniel L

AU - Hunt, Kelly J

AU - Lyons, Timothy J

AU - Jenkins, Alicia J

AU - Virella, Gabriel

AU - DCCT/EDIC Study Group

PY - 2012/6

Y1 - 2012/6

N2 - To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.

AB - To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.

KW - Adult

KW - Albuminuria

KW - Biological Markers

KW - Cholesterol, LDL

KW - Diabetes Mellitus, Type 1

KW - Diabetic Retinopathy

KW - Disease Progression

KW - Female

KW - Glycosylation End Products, Advanced

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Lipoproteins, LDL

KW - Male

KW - Proportional Hazards Models

KW - Risk Factors

U2 - 10.2337/dc11-2040

DO - 10.2337/dc11-2040

M3 - Article

C2 - 22511260

SN - 0149-5992

VL - 35

SP - 1333

EP - 1340

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Abstract

Keywords

UN SDGs

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