High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Maria F Lopes-Virella; Nathaniel L Baker; Kelly J Hunt; Timothy J Lyons; Alicia J Jenkins; Gabriel Virella; DCCT/EDIC Study Group

doi:10.2337/dc11-2040

High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Maria F Lopes-Virella
, Nathaniel L Baker
, Kelly J Hunt
, Timothy J Lyons
, Alicia J Jenkins
, Gabriel Virella
, DCCT/EDIC Study Group

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.

Original language	English
Pages (from-to)	1333-40
Number of pages	8
Journal	Diabetes Care
Volume	35
Issue number	6
DOIs	https://doi.org/10.2337/dc11-2040
Publication status	Published - Jun 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Albuminuria
Biological Markers
Cholesterol, LDL
Diabetes Mellitus, Type 1
Diabetic Retinopathy
Disease Progression
Female
Glycosylation End Products, Advanced
Hemoglobin A, Glycosylated
Humans
Lipoproteins, LDL
Male
Proportional Hazards Models
Risk Factors

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10.2337/dc11-2040

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@article{a646437c08b04f74aa4827646804964a,

title = "High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes",

abstract = "To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.",

keywords = "Adult, Albuminuria, Biological Markers, Cholesterol, LDL, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Disease Progression, Female, Glycosylation End Products, Advanced, Hemoglobin A, Glycosylated, Humans, Lipoproteins, LDL, Male, Proportional Hazards Models, Risk Factors",

author = "Lopes-Virella, \{Maria F\} and Baker, \{Nathaniel L\} and Hunt, \{Kelly J\} and Lyons, \{Timothy J\} and Jenkins, \{Alicia J\} and Gabriel Virella and \{DCCT/EDIC Study Group\}",

year = "2012",

month = jun,

doi = "10.2337/dc11-2040",

language = "English",

volume = "35",

pages = "1333--40",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "6",

}

TY - JOUR

T1 - High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

AU - Lopes-Virella, Maria F

AU - Baker, Nathaniel L

AU - Hunt, Kelly J

AU - Lyons, Timothy J

AU - Jenkins, Alicia J

AU - Virella, Gabriel

AU - DCCT/EDIC Study Group

PY - 2012/6

Y1 - 2012/6

N2 - To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.

AB - To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes.

KW - Adult

KW - Albuminuria

KW - Biological Markers

KW - Cholesterol, LDL

KW - Diabetes Mellitus, Type 1

KW - Diabetic Retinopathy

KW - Disease Progression

KW - Female

KW - Glycosylation End Products, Advanced

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Lipoproteins, LDL

KW - Male

KW - Proportional Hazards Models

KW - Risk Factors

U2 - 10.2337/dc11-2040

DO - 10.2337/dc11-2040

M3 - Article

C2 - 22511260

SN - 0149-5992

VL - 35

SP - 1333

EP - 1340

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

Abstract

UN SDGs

Keywords

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