Multi-MeV ions and fusion neutrons were generated by focused radiation of the 3-TW Prague Asterix Laser System (PALS). In our experiments a maximum proton energy of about 4 MeV was generated by a laser irradiance Iλ 2~5×1016 W cm-2 μm2 on target, which is nominally reachable at Iλ2~3×1018 W cm-2 μm2 for picosecond-class lasers [1,2]. This value of 4 MeV well correlates with the proton scaling law obtained experimentally at the Omega EP facility from 10-ps laser pulses . When a massive deuterated polyethylene target was exposed to the laser intensity of about 3×10 16 W/cm2 a neutron yield of about 3×108 neutrons per shot was recorded. Moreover, the deuterons emitted from the target front surface had enough energy to produce high energy neutrons through the 7Li(d,xn) reaction when impinging a LiF slab.