High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

Jane McEneny*, Sarah Blair, Jayne V. Woodside, Liam Murray, Colin Boreham, Ian S. Young

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

BACKGROUND: In adults, obesity-driven inflammation can lead to increased cardiovascular disease (CVD). However, information regarding childhood obesity and its inflammatory sequelae is less well defined. Serum amyloid-A (SAA) is an inflammatory molecule that rapidly associates with high-density lipoproteins (HDLs) and renders them dysfunctional. Therefore, SAA may be a useful biomarker to identify increased CVD potential in overweight and obese children.

METHODS: Young Hearts 2000 is a cross-sectional cohort study in which 92 children who were obese were matched for age and sex with 92 overweight and 92 lean children. HDL2 and HDL3 (HDL2&3) were isolated from plasma by a three-step rapid-ultracentrifugation procedure. SAA was measured in serum and HDL2&3 by an enzyme-linked immunosorbent assay procedure, and the activities of cholesterol ester transfer protein (CETP) and lecithin cholesteryl acyltransferase (LCAT) were measured by fluorimetric assays.

RESULTS: Trends across the groups indicated that SAA increased in serum and HDL2&3 as BMI increased, as did HDL2-CETP and HDL2-LCAT activities.

CONCLUSION: These results have provided evidence that overweight and obese children are exposed to an inflammatory milieu that impacts the antiatherogenic properties of HDL and that could increase CVD risk. This supports the concept that it is important to target childhood obesity to help minimize future cardiovascular events.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalPediatric Research
Volume74
Issue number3
Early online date24 Jul 2013
DOIs
Publication statusPublished - Sep 2013

Keywords

  • SERUM-AMYLOID-A
  • AMERICAN-HEART-ASSOCIATION
  • LOW-GRADE INFLAMMATION
  • ESTER TRANSFER PROTEIN
  • SYSTEMIC INFLAMMATION
  • INSULIN-RESISTANCE
  • RISK-FACTORS
  • LIFE-STYLE
  • ADOLESCENTS
  • DISEASE

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children'. Together they form a unique fingerprint.

Cite this