High dose bystander effects in spatially fractionated radiation therapy

Rajalakshmi Asur, Karl T Butterworth, Jose A Penagaricano, Kevin M Prise, Robert J Griffin

Research output: Contribution to journalSpecial issuepeer-review

56 Citations (Scopus)
556 Downloads (Pure)


Traditional radiotherapy of bulky tumors has certain limitations. Spatially fractionated radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of advanced modulated beam therapies that help in significant reductions in normal tissue damage. GRID refers to the delivery of a single high dose of radiation to a large treatment area that is divided into several smaller fields, while IMRT allows improved dose conformity to the tumor target compared to conventional three-dimensional conformal radiotherapy. In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalCancer Letters
Issue number1
Early online date15 Nov 2013
Publication statusPublished - 01 Jan 2015


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