High PTGS2 expression in post neoadjuvant chemotherapy treated oesophageal adenocarcinoma is associated with improved survival: a population-based cohort study

Andrew Spence, James Trainor, Una McMenamin, Richard Turkington, Stephen McQuaid, Victoria Bingham, Jacqueline James, Manuel Salto-Tellez, Damian McManus, Brian Johnston, Christopher Cardwell, Helen Coleman

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Abstract

Aims
High prostaglandin endoperoxide synthase‐2 (PTGS2) enzyme expression in oesophageal adenocarcinoma has been shown to independently predict poor prognosis, however evidence is inconsistent. We investigated the association between PTGS2 expression and prognosis in patients with oesophageal adenocarcinoma.

Methods and results
A cohort of 135 patients with oesophageal adenocarcinoma who received neoadjuvant chemotherapy and surgery from 2004 to 2012 was identified in the Northern Ireland Cancer Centre. Tissue microarrays were created in the Northern Ireland Biobank, sampling triplicate cores from each tumour. Immunohistochemical PTGS2 expression was scored by two independent assessors with intensity and proportion of tumour staining used to calculate H‐scores for each patient. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (95% CIs) for overall and cancer‐specific survival, and recurrence‐free survival by PTGS2 expression, adjusting for potential confounders. Patients were followed up for a mean of 3.0 (SD 1.8) years. The PTGS2 expression cut‐off value was determined using the median H‐score of the cohort (270/300). High (n=79), compared to low (n=56), PTGS2 expression was associated with improved cancer‐specific survival (adjusted HR 0.56, 95% CI 0.33‐0.94; p=0.03). PTGS2 expression was not significantly associated with recurrence‐free survival (adjusted HR 0.85, 95% CI 0.52‐1.38; p=0.51).

Conclusions
High PTGS2 expression in oesophageal adenocarcinoma tissue was associated with improved overall and cancer‐specific survival, contrasting previous evidence. As this is the first study of its kind to include patients who had undergone neoadjuvant chemotherapy further studies are needed to clarify these associations.
Original languageEnglish
Pages (from-to)1-24
JournalHistopathology
Early online date08 Nov 2018
DOIs
Publication statusEarly online date - 08 Nov 2018

Keywords

  • biomarker
  • epidemiology
  • oesophageal cancer
  • PTGS2 expression
  • Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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