Highly selective, first-in-class furin inhibitor BOS-318 inhibits ENaC and restores airway hydration in cystic fibrosis

L. Douglas; J. Reihill; M. Ho; J. Axten; N. Campobasso; K.  Wilcoxen; S.  Martin

doi:10.1016/S1569-1993(21)01815-4

Highly selective, first-in-class furin inhibitor BOS-318 inhibits ENaC and restores airway hydration in cystic fibrosis

L. Douglas, J. Reihill, M. Ho, J. Axten, N. Campobasso, K. Wilcoxen, S. Martin^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Meeting abstract › peer-review

Original language	English
Article number	391
Pages (from-to)	S185
Number of pages	1
Journal	Journal of Cystic Fibrosis
Volume	20
Issue number	Supplement 2
Early online date	15 Oct 2021
DOIs	https://doi.org/10.1016/S1569-1993(21)01815-4
Publication status	Published - 01 Nov 2021
Event	2021 North American Cystic Fibrosis Conference (NACFC) - Duration: 02 Nov 2021 → 05 Nov 2021

Access to Document

10.1016/S1569-1993(21)01815-4Licence: Unspecified

1 Finished
1 Active

R8874PMY: Inhibition of Furin as a Strategy for Treatment of hronic Airways disease
Martin, L. (PI)
30/10/2019 → …
Project: Research
R8875PMY: Investigation of Furin as a Target for Airways Disease
Martin, L. (PI)
01/11/2019 → 04/05/2021
Project: Research

1 Participation in conference

2021 North American Cystic Fibrosis Conference (NACFC)
Martin, L. (Participant)
02 Nov 2021 → 05 Nov 2021
Activity: Participating in or organising an event types › Participation in conference

1 Article
1 Review article

Furin as a therapeutic target in cystic fibrosis airways disease
Douglas, L. E. J., Reihill, J. A., Montgomery, B. M. & Martin, S. L., 30 Jun 2023, In: European Respiratory Review. 32, 168, 14 p., 220256.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
6 Citations (Scopus)

46 Downloads (Pure)
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airways disease
Douglas, L. E. J., Reihill, J. A., Ho, M. W. Y., Axten, J. M., Campobasso, N., Schneck, J. L., Rendina, A. R., Wilcoxen, K. M. & Martin, S. L., 16 Jun 2022, In: Cell Chemical Biology. 29, 6, p. P947-957.E8
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Citations (Scopus)

101 Downloads (Pure)

Cite this

@article{22ab073e36ff486d810cd08f5651d8e5,

title = "Highly selective, first-in-class furin inhibitor BOS-318 inhibits ENaC and restores airway hydration in cystic fibrosis",

author = "L. Douglas and J. Reihill and M. Ho and J. Axten and N. Campobasso and K. Wilcoxen and S. Martin",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/S1569-1993(21)01815-4",

language = "English",

volume = "20",

pages = "S185",

journal = "Journal of Cystic Fibrosis",

issn = "1569-1993",

publisher = "Elsevier B.V.",

number = "Supplement 2",

note = "2021 North American Cystic Fibrosis Conference (NACFC) ; Conference date: 02-11-2021 Through 05-11-2021",

}

TY - JOUR

T1 - Highly selective, first-in-class furin inhibitor BOS-318 inhibits ENaC and restores airway hydration in cystic fibrosis

AU - Douglas, L.

AU - Reihill, J.

AU - Ho, M.

AU - Axten, J.

AU - Campobasso, N.

AU - Wilcoxen, K.

AU - Martin, S.

PY - 2021/11/1

Y1 - 2021/11/1

U2 - 10.1016/S1569-1993(21)01815-4

DO - 10.1016/S1569-1993(21)01815-4

M3 - Meeting abstract

SN - 1569-1993

VL - 20

SP - S185

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - Supplement 2

M1 - 391

T2 - 2021 North American Cystic Fibrosis Conference (NACFC)

Y2 - 2 November 2021 through 5 November 2021

ER -

Highly selective, first-in-class furin inhibitor BOS-318 inhibits ENaC and restores airway hydration in cystic fibrosis

Access to Document

Projects

R8874PMY: Inhibition of Furin as a Strategy for Treatment of hronic Airways disease

R8875PMY: Investigation of Furin as a Target for Airways Disease

Activities

2021 North American Cystic Fibrosis Conference (NACFC)

Research output

Furin as a therapeutic target in cystic fibrosis airways disease

A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airways disease

Cite this