Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease

Lisa Douglas; James Reihill; Tatjana Odrljin; Lorraine Martin

doi:10.1183/13993003.congress-2023.PA1868

Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease

Lisa Douglas, James Reihill, Tatjana Odrljin, Lorraine Martin^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Meeting abstract › peer-review

Original language	English
Article number	PA1868
Journal	European Respiratory Journal
Volume	62
Issue number	suppl 67
Early online date	27 Oct 2023
DOIs	https://doi.org/10.1183/13993003.congress-2023.PA1868
Publication status	Published - 01 Nov 2023
Event	European Respiratory Society International Congress 2023 - Milan, Italy Duration: 09 Sept 2023 → 13 Sept 2023 https://www.ersnet.org/congress-and-events/congress/

Keywords

furin
COPD
protease inhibitor
ENaC
mucociliary clearance

Access to Document

10.1183/13993003.congress-2023.PA1868Licence: Unspecified

1 Finished

R8875PMY: Investigation of Furin as a Target for Airways Disease
Martin, L. (PI)
01/11/2019 → 04/05/2021
Project: Research

1 Article
1 Review article

Furin as a therapeutic target in cystic fibrosis airways disease
Douglas, L. E. J., Reihill, J. A., Montgomery, B. M. & Martin, S. L., 30 Jun 2023, In: European Respiratory Review. 32, 168, 14 p., 220256.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
6 Citations (Scopus)

51 Downloads (Pure)
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airways disease
Douglas, L. E. J., Reihill, J. A., Ho, M. W. Y., Axten, J. M., Campobasso, N., Schneck, J. L., Rendina, A. R., Wilcoxen, K. M. & Martin, S. L., 16 Jun 2022, In: Cell Chemical Biology. 29, 6, p. P947-957.E8
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Citations (Scopus)

105 Downloads (Pure)

Cite this

@article{ea2b4746ed324c739d5bd7d72876819b,

title = "Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease",

keywords = "furin, COPD, protease inhibitor, ENaC, mucociliary clearance",

author = "Lisa Douglas and James Reihill and Tatjana Odrljin and Lorraine Martin",

year = "2023",

month = nov,

day = "1",

doi = "10.1183/13993003.congress-2023.PA1868",

language = "English",

volume = "62",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "suppl 67",

note = "European Respiratory Society International Congress 2023, ERS 2023 ; Conference date: 09-09-2023 Through 13-09-2023",

url = "https://www.ersnet.org/congress-and-events/congress/",

}

TY - JOUR

T1 - Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease

AU - Douglas, Lisa

AU - Reihill, James

AU - Odrljin, Tatjana

AU - Martin, Lorraine

PY - 2023/11/1

Y1 - 2023/11/1

KW - furin

KW - COPD

KW - protease inhibitor

KW - ENaC

KW - mucociliary clearance

U2 - 10.1183/13993003.congress-2023.PA1868

DO - 10.1183/13993003.congress-2023.PA1868

M3 - Meeting abstract

SN - 0903-1936

VL - 62

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - suppl 67

M1 - PA1868

T2 - European Respiratory Society International Congress 2023

Y2 - 9 September 2023 through 13 September 2023

ER -

Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease

Keywords

Access to Document

Projects

R8875PMY: Investigation of Furin as a Target for Airways Disease

Research output

Furin as a therapeutic target in cystic fibrosis airways disease

A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airways disease

Cite this