Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

Anna Zampetaki, Lingfang Zeng, Andriana Margariti, Qingzhong Xiao, Hongling Li, Zhongyi Zhang, Anna Elena Pepe, Gang Wang, Ouassila Habi, Elena deFalco, Gillian Cockerill, Justin C Mason, Yanhua Hu, Qingbo Xu

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3 in preserving endothelial integrity in areas of disturbed blood flow, ie, bifurcation areas prone to atherosclerosis development.
Original languageEnglish
Pages (from-to)132-42
Number of pages11
JournalCirculation
Volume121
Issue number1
DOIs
Publication statusPublished - 2010

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    Zampetaki, A., Zeng, L., Margariti, A., Xiao, Q., Li, H., Zhang, Z., Pepe, A. E., Wang, G., Habi, O., deFalco, E., Cockerill, G., Mason, J. C., Hu, Y., & Xu, Q. (2010). Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation, 121(1), 132-42. https://doi.org/10.1161/CIRCULATIONAHA.109.890491