Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

Anna Zampetaki; Lingfang Zeng; Andriana Margariti; Qingzhong Xiao; Hongling Li; Zhongyi Zhang; Anna Elena Pepe; Gang Wang; Ouassila Habi; Elena deFalco; Gillian Cockerill; Justin C Mason; Yanhua Hu; Qingbo Xu

doi:10.1161/CIRCULATIONAHA.109.890491

Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

Anna Zampetaki, Lingfang Zeng, Andriana Margariti, Qingzhong Xiao, Hongling Li, Zhongyi Zhang, Anna Elena Pepe, Gang Wang, Ouassila Habi, Elena deFalco, Gillian Cockerill, Justin C Mason, Yanhua Hu, Qingbo Xu

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142 Citations (Scopus)

Abstract

Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3 in preserving endothelial integrity in areas of disturbed blood flow, ie, bifurcation areas prone to atherosclerosis development.

Original language	English
Pages (from-to)	132-42
Number of pages	11
Journal	Circulation
Volume	121
Issue number	1
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.109.890491
Publication status	Published - 2010

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10.1161/CIRCULATIONAHA.109.890491

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title = "Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow",

abstract = "Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3 in preserving endothelial integrity in areas of disturbed blood flow, ie, bifurcation areas prone to atherosclerosis development.",

author = "Anna Zampetaki and Lingfang Zeng and Andriana Margariti and Qingzhong Xiao and Hongling Li and Zhongyi Zhang and Pepe, {Anna Elena} and Gang Wang and Ouassila Habi and Elena deFalco and Gillian Cockerill and Mason, {Justin C} and Yanhua Hu and Qingbo Xu",

year = "2010",

doi = "10.1161/CIRCULATIONAHA.109.890491",

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T1 - Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

AU - Zampetaki, Anna

AU - Zeng, Lingfang

AU - Margariti, Andriana

AU - Xiao, Qingzhong

AU - Li, Hongling

AU - Zhang, Zhongyi

AU - Pepe, Anna Elena

AU - Wang, Gang

AU - Habi, Ouassila

AU - deFalco, Elena

AU - Cockerill, Gillian

AU - Mason, Justin C

AU - Hu, Yanhua

AU - Xu, Qingbo

PY - 2010

Y1 - 2010

N2 - Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3 in preserving endothelial integrity in areas of disturbed blood flow, ie, bifurcation areas prone to atherosclerosis development.

AB - Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3 in preserving endothelial integrity in areas of disturbed blood flow, ie, bifurcation areas prone to atherosclerosis development.

U2 - 10.1161/CIRCULATIONAHA.109.890491

DO - 10.1161/CIRCULATIONAHA.109.890491

M3 - Article

C2 - 20026773

SN - 1524-4539

VL - 121

SP - 132

EP - 142

JO - Circulation

JF - Circulation

IS - 1

ER -

Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

Abstract

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