Homocysteine and B-group vitamins in renal transplant patients

Jayne Woodside, Damian Fogarty, Janet Lightbody, Clodagh Loughrey, John Yarnell, Alexander Maxwell, Ian Young

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Increased plasma homocysteine is an independent risk factor for cardiovascular disease. We have investigated homocysteine and B-group vitamin levels in renal transplant patients. Fasting blood was collected from 55 renal transplant recipients with good renal function and 32 age/sex matched control subjects. Total homocysteine was increased in transplant recipients in comparison to controls (10.9+/-1.5 vs. 6.7+/-1.3 micromol/l, P < 0.001). There was no difference in homocysteine between patients receiving cyclosporin (n = 39, homocysteine 11.0+/-1.5 micromol/l) and patients receiving prednisolone + azathioprine (n = 16, 10.8+/-1.6 micromol/l, mean+/-S.D.), although there was a significant correlation between homocysteine and serum cyclosporin concentration in the sub-group of patients receiving that immunosuppressive regimen (r = 0.42, P < 0.05). Levels of B-group vitamins were similar in patients and controls. Plasma homocysteine is increased in renal transplant recipients even in the presence of minor degrees of renal impairment and normal levels of B-group vitamins.
Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalClinica chimica acta; international journal of clinical chemistry
Issue number1-2
Publication statusPublished - 01 Apr 1999

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry


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