Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

Y Dombrowski, M Peric, S Koglin, N Kaymakanov, V Schmezer, M Reinholz, T Ruzicka, J Schauber

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey bee venom (BV) allergies are very common; however, the local inflammatory cascade leading to the initiation of allergic sensitization is poorly understood. In this study, the local inflammatory cascades in skin after exposure to BV were investigated.
Original languageEnglish
Pages (from-to)1400-7
Number of pages8
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume67
Issue number11
DOIs
Publication statusPublished - Nov 2012

Bibliographical note

© 2012 John Wiley & Sons A/S.

Keywords

  • Animals
  • Bee Venoms
  • Bees
  • Cells, Cultured
  • DNA, Mitochondrial
  • Humans
  • Inflammasomes
  • Interleukin-18
  • Interleukin-1beta
  • Keratinocytes
  • Melitten
  • Mitochondrial Membranes
  • Nuclear Proteins

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