Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey bee venom (BV) allergies are very common; however, the local inflammatory cascade leading to the initiation of allergic sensitization is poorly understood. In this study, the local inflammatory cascades in skin after exposure to BV were investigated.
|Number of pages||8|
|Journal||Allergy: European Journal of Allergy and Clinical Immunology|
|Publication status||Published - Nov 2012|
Bibliographical note© 2012 John Wiley & Sons A/S.
- Bee Venoms
- Cells, Cultured
- DNA, Mitochondrial
- Mitochondrial Membranes
- Nuclear Proteins