Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

Y Dombrowski; M Peric; S Koglin; N Kaymakanov; V Schmezer; M Reinholz; T Ruzicka; J Schauber

doi:10.1111/all.12022

Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

Y Dombrowski, M Peric, S Koglin, N Kaymakanov, V Schmezer, M Reinholz, T Ruzicka, J Schauber

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey bee venom (BV) allergies are very common; however, the local inflammatory cascade leading to the initiation of allergic sensitization is poorly understood. In this study, the local inflammatory cascades in skin after exposure to BV were investigated.

Original language	English
Pages (from-to)	1400-7
Number of pages	8
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	67
Issue number	11
DOIs	https://doi.org/10.1111/all.12022
Publication status	Published - Nov 2012

Bibliographical note

Keywords

Animals
Bee Venoms
Bees
Cells, Cultured
DNA, Mitochondrial
Humans
Inflammasomes
Interleukin-18
Interleukin-1beta
Keratinocytes
Melitten
Mitochondrial Membranes
Nuclear Proteins

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10.1111/all.12022

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title = "Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes",

abstract = "Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey bee venom (BV) allergies are very common; however, the local inflammatory cascade leading to the initiation of allergic sensitization is poorly understood. In this study, the local inflammatory cascades in skin after exposure to BV were investigated.",

keywords = "Animals, Bee Venoms, Bees, Cells, Cultured, DNA, Mitochondrial, Humans, Inflammasomes, Interleukin-18, Interleukin-1beta, Keratinocytes, Melitten, Mitochondrial Membranes, Nuclear Proteins",

author = "Y Dombrowski and M Peric and S Koglin and N Kaymakanov and V Schmezer and M Reinholz and T Ruzicka and J Schauber",

note = "{\textcopyright} 2012 John Wiley \& Sons A/S.",

year = "2012",

month = nov,

doi = "10.1111/all.12022",

language = "English",

volume = "67",

pages = "1400--7",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

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publisher = "Wiley-Blackwell",

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T1 - Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

AU - Dombrowski, Y

AU - Peric, M

AU - Koglin, S

AU - Kaymakanov, N

AU - Schmezer, V

AU - Reinholz, M

AU - Ruzicka, T

AU - Schauber, J

PY - 2012/11

Y1 - 2012/11

N2 - Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey bee venom (BV) allergies are very common; however, the local inflammatory cascade leading to the initiation of allergic sensitization is poorly understood. In this study, the local inflammatory cascades in skin after exposure to BV were investigated.

AB - Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey bee venom (BV) allergies are very common; however, the local inflammatory cascade leading to the initiation of allergic sensitization is poorly understood. In this study, the local inflammatory cascades in skin after exposure to BV were investigated.

KW - Animals

KW - Bee Venoms

KW - Bees

KW - Cells, Cultured

KW - DNA, Mitochondrial

KW - Humans

KW - Inflammasomes

KW - Interleukin-18

KW - Interleukin-1beta

KW - Keratinocytes

KW - Melitten

KW - Mitochondrial Membranes

KW - Nuclear Proteins

U2 - 10.1111/all.12022

DO - 10.1111/all.12022

M3 - Article

C2 - 22973906

SN - 0105-4538

VL - 67

SP - 1400

EP - 1407

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 11

ER -

Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

Abstract

Bibliographical note

Keywords

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