How can clinical research improve European health outcomes in cancer?

Peter Selby*, Lifang Liu, Amy Downing, Ian Banks, Roger Wilson, Richard Stephens, Francoise Meunier, Justine Rochon, Eva Morris, Matt Seymour, Walter Gregory, Mark Lawler, Annette Boaz

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

We review the mechanisms by which clinical cancer research can improve health outcomes and argue that this should be central to the development of policy. Recent series of major international studies have analysed large, often nationwide, datasets for cancer patient outcomes and participation in clinical research. They have evaluated and quantified the impact of new evidence generated by randomised controlled trials on cancer survival. They show a strong and probably causal relationship between the participation in clinical research in hospitals and the outcomes for patients with the disease under study in those hospitals. Also, institutions that are active in clinical trials appear to take up well evidenced innovations more rapidly than those which are not so engaged. Further work is necessary to confirm and examine the generalisability of these findings but we argue that all of these mechanisms are likely to lead to improved outcomes for patients as a consequence of the conduct of clinical research. The size of the benefit appears to be substantial and an active programme to promote clinical research across cancer care systems should be a part of National Cancer Plans and Cancer Control Strategies.

Original languageEnglish
Article number100182
Number of pages6
JournalJournal of Cancer Policy
Volume20
Early online date01 Feb 2019
DOIs
Publication statusPublished - 01 Jun 2019

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Health
Research
Neoplasms
Patient Participation
Policy Making
Randomized Controlled Trials
Clinical Trials
Survival

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Selby, P., Liu, L., Downing, A., Banks, I., Wilson, R., Stephens, R., ... Boaz, A. (2019). How can clinical research improve European health outcomes in cancer? Journal of Cancer Policy, 20, [100182]. https://doi.org/10.1016/j.jcpo.2019.100182
Selby, Peter ; Liu, Lifang ; Downing, Amy ; Banks, Ian ; Wilson, Roger ; Stephens, Richard ; Meunier, Francoise ; Rochon, Justine ; Morris, Eva ; Seymour, Matt ; Gregory, Walter ; Lawler, Mark ; Boaz, Annette. / How can clinical research improve European health outcomes in cancer?. In: Journal of Cancer Policy. 2019 ; Vol. 20.
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Selby, P, Liu, L, Downing, A, Banks, I, Wilson, R, Stephens, R, Meunier, F, Rochon, J, Morris, E, Seymour, M, Gregory, W, Lawler, M & Boaz, A 2019, 'How can clinical research improve European health outcomes in cancer?', Journal of Cancer Policy, vol. 20, 100182. https://doi.org/10.1016/j.jcpo.2019.100182

How can clinical research improve European health outcomes in cancer? / Selby, Peter; Liu, Lifang; Downing, Amy; Banks, Ian; Wilson, Roger; Stephens, Richard; Meunier, Francoise; Rochon, Justine; Morris, Eva; Seymour, Matt; Gregory, Walter; Lawler, Mark; Boaz, Annette.

In: Journal of Cancer Policy, Vol. 20, 100182, 01.06.2019.

Research output: Contribution to journalReview article

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AU - Rochon, Justine

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Selby P, Liu L, Downing A, Banks I, Wilson R, Stephens R et al. How can clinical research improve European health outcomes in cancer? Journal of Cancer Policy. 2019 Jun 1;20. 100182. https://doi.org/10.1016/j.jcpo.2019.100182