How can clinical research improve European health outcomes in cancer?

Peter Selby*, Lifang Liu, Amy Downing, Ian Banks, Roger Wilson, Richard Stephens, Francoise Meunier, Justine Rochon, Eva Morris, Matt Seymour, Walter Gregory, Mark Lawler, Annette Boaz

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


We review the mechanisms by which clinical cancer research can improve health outcomes and argue that this should be central to the development of policy. Recent series of major international studies have analysed large, often nationwide, datasets for cancer patient outcomes and participation in clinical research. They have evaluated and quantified the impact of new evidence generated by randomised controlled trials on cancer survival. They show a strong and probably causal relationship between the participation in clinical research in hospitals and the outcomes for patients with the disease under study in those hospitals. Also, institutions that are active in clinical trials appear to take up well evidenced innovations more rapidly than those which are not so engaged. Further work is necessary to confirm and examine the generalisability of these findings but we argue that all of these mechanisms are likely to lead to improved outcomes for patients as a consequence of the conduct of clinical research. The size of the benefit appears to be substantial and an active programme to promote clinical research across cancer care systems should be a part of National Cancer Plans and Cancer Control Strategies.

Original languageEnglish
Article number100182
Number of pages6
JournalJournal of Cancer Policy
Early online date01 Feb 2019
Publication statusPublished - 01 Jun 2019

ASJC Scopus subject areas

  • Oncology
  • Health Policy


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