HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

C.E. Lebert-Ghali; M. Fournier; Glenda Dickson; Alexander Thompson; G. Sauvageau; J.J. Bijl

doi:10.1016/j.exphem.2010.07.006

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

C.E. Lebert-Ghali, M. Fournier, Glenda Dickson, Alexander Thompson, G. Sauvageau, J.J. Bijl

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30 Citations (Scopus)

Abstract

Functional compensation between homeodomain proteins has hindered the ability to unravel their role in hematopoiesis using single gene knockouts. Because HoxB genes are dispensable for hematopoiesis, and most HoxA genes are expressed an order of magnitude higher than other cluster genes in hematopoietic stem cell (HSC)-enriched populations, we hypothesize that maintenance of HoxA cluster expression is important for adult hematopoiesis and that global decrease of HoxA gene expression levels affects steady-state hematopoiesis.

Original language	English
Pages (from-to)	1074-1086
Number of pages	13
Journal	Experimental Hematology
Volume	38
Issue number	11
DOIs	https://doi.org/10.1016/j.exphem.2010.07.006
Publication status	Published - Nov 2010

Bibliographical note

ASJC Scopus subject areas

Cancer Research
Cell Biology
Genetics
Molecular Biology
Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.exphem.2010.07.006

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title = "HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells",

abstract = "Functional compensation between homeodomain proteins has hindered the ability to unravel their role in hematopoiesis using single gene knockouts. Because HoxB genes are dispensable for hematopoiesis, and most HoxA genes are expressed an order of magnitude higher than other cluster genes in hematopoietic stem cell (HSC)-enriched populations, we hypothesize that maintenance of HoxA cluster expression is important for adult hematopoiesis and that global decrease of HoxA gene expression levels affects steady-state hematopoiesis.",

author = "C.E. Lebert-Ghali and M. Fournier and Glenda Dickson and Alexander Thompson and G. Sauvageau and J.J. Bijl",

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T1 - HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

AU - Lebert-Ghali, C.E.

AU - Fournier, M.

AU - Dickson, Glenda

AU - Thompson, Alexander

AU - Sauvageau, G.

AU - Bijl, J.J.

PY - 2010/11

Y1 - 2010/11

N2 - Functional compensation between homeodomain proteins has hindered the ability to unravel their role in hematopoiesis using single gene knockouts. Because HoxB genes are dispensable for hematopoiesis, and most HoxA genes are expressed an order of magnitude higher than other cluster genes in hematopoietic stem cell (HSC)-enriched populations, we hypothesize that maintenance of HoxA cluster expression is important for adult hematopoiesis and that global decrease of HoxA gene expression levels affects steady-state hematopoiesis.

AB - Functional compensation between homeodomain proteins has hindered the ability to unravel their role in hematopoiesis using single gene knockouts. Because HoxB genes are dispensable for hematopoiesis, and most HoxA genes are expressed an order of magnitude higher than other cluster genes in hematopoietic stem cell (HSC)-enriched populations, we hypothesize that maintenance of HoxA cluster expression is important for adult hematopoiesis and that global decrease of HoxA gene expression levels affects steady-state hematopoiesis.

U2 - 10.1016/j.exphem.2010.07.006

DO - 10.1016/j.exphem.2010.07.006

M3 - Article

C2 - 20655978

SN - 1873-2399

VL - 38

SP - 1074

EP - 1086

JO - Experimental Hematology

JF - Experimental Hematology

IS - 11

ER -

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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