HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

C.E. Lebert-Ghali, M. Fournier, Glenda Dickson, Alexander Thompson, G. Sauvageau, J.J. Bijl

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Functional compensation between homeodomain proteins has hindered the ability to unravel their role in hematopoiesis using single gene knockouts. Because HoxB genes are dispensable for hematopoiesis, and most HoxA genes are expressed an order of magnitude higher than other cluster genes in hematopoietic stem cell (HSC)-enriched populations, we hypothesize that maintenance of HoxA cluster expression is important for adult hematopoiesis and that global decrease of HoxA gene expression levels affects steady-state hematopoiesis.
Original languageEnglish
Pages (from-to)1074-1086
Number of pages13
JournalExperimental Hematology
Volume38
Issue number11
DOIs
Publication statusPublished - Nov 2010

Bibliographical note

Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved.

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Hematology

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    Lebert-Ghali, C. E., Fournier, M., Dickson, G., Thompson, A., Sauvageau, G., & Bijl, J. J. (2010). HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells. Experimental Hematology, 38(11), 1074-1086. https://doi.org/10.1016/j.exphem.2010.07.006