Functional compensation between homeodomain proteins has hindered the ability to unravel their role in hematopoiesis using single gene knockouts. Because HoxB genes are dispensable for hematopoiesis, and most HoxA genes are expressed an order of magnitude higher than other cluster genes in hematopoietic stem cell (HSC)-enriched populations, we hypothesize that maintenance of HoxA cluster expression is important for adult hematopoiesis and that global decrease of HoxA gene expression levels affects steady-state hematopoiesis.
Bibliographical noteCrown Copyright © 2010. Published by Elsevier Inc. All rights reserved.
ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Molecular Biology
Lebert-Ghali, C. E., Fournier, M., Dickson, G., Thompson, A., Sauvageau, G., & Bijl, J. J. (2010). HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells. Experimental Hematology, 38(11), 1074-1086. https://doi.org/10.1016/j.exphem.2010.07.006