HOXB13, RFX6 and prostate cancer risk

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.

Original languageEnglish
Pages (from-to)94-5
Number of pages2
JournalNature Genetics
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Chromatin
  • Chromosomes, Human, Pair 6
  • DNA-Binding Proteins
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Homeodomain Proteins
  • Humans
  • Male
  • Prostatic Neoplasms
  • Transcription Factors

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