A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.
- Chromosomes, Human, Pair 6
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Homeodomain Proteins
- Prostatic Neoplasms
- Transcription Factors