Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Jonathan E. Ross, Peter C. Knipe, Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions.

Original languageEnglish
Pages (from-to)13518-13521
Number of pages4
JournalChemistry - A European Journal
Volume21
Issue number39
Early online date11 Aug 2015
DOIs
Publication statusPublished - 10 Sep 2015

Keywords

  • foldamer
  • peptidomimetics
  • protein surface
  • protein-protein interaction
  • secondary structure
  • β-sheet

ASJC Scopus subject areas

  • Medicine(all)

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