Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Jonathan E. Ross; Peter C. Knipe; Sam Thompson; Andrew D. Hamilton

doi:10.1002/chem.201502690

Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Jonathan E. Ross
, Peter C. Knipe
, Sam Thompson
, Andrew D. Hamilton

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

128 Downloads (Pure)

Abstract

Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions.

Original language	English
Pages (from-to)	13518-13521
Number of pages	4
Journal	Chemistry - A European Journal
Volume	21
Issue number	39
Early online date	11 Aug 2015
DOIs	https://doi.org/10.1002/chem.201502690
Publication status	Published - 10 Sept 2015

Keywords

foldamer
peptidomimetics
protein surface
protein-protein interaction
secondary structure
β-sheet

ASJC Scopus subject areas

General Medicine

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Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation
Copyright 2015 Wiley-VCHGmbH. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 2.01 MBLicence: Unspecified

Cite this

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AU - Thompson, Sam

AU - Hamilton, Andrew D.

PY - 2015/9/10

Y1 - 2015/9/10

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AB - Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions.

KW - foldamer

KW - peptidomimetics

KW - protein surface

KW - protein-protein interaction

KW - secondary structure

KW - β-sheet

U2 - 10.1002/chem.201502690

DO - 10.1002/chem.201502690

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 39

ER -

Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Abstract

Keywords

ASJC Scopus subject areas

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