Hydration of sulfobetaine dizwitterions as a function of alkyl spacer length

Oliver S. Hammond, Gaelle Level, Leila Moura, Silvia Imberti, John Holbrey*, Marijana Blesic*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
85 Downloads (Pure)


The solvation and structure of bolaform dizwitterions containing two sulfobetaine moieties in concentrated aqueous solution were determined using neutron diffraction with isotopic substitution (NDIS) combined with modelling of the measured structure factors using Empirical Potential Structure Refinement (EPSR). Strongly directional local hydration was observed in the polar regimes of the dizwitterions with 48–52 water molecules shared between dizwitterion molecules in a first shell water network around each zwitterion pair. Overall, the double zwitterions were highly hydrated, providing experimental evidence in support of the potential formation of protein-resistant hydration layers at zwitterion-water interfaces.
Original languageEnglish
Pages (from-to)16040-16050
Number of pages11
JournalPhysical Chemistry Chemical Physics (PCCP)
Early online date29 Jun 2020
Publication statusEarly online date - 29 Jun 2020


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