Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

John G. Hardy, Eneko Larrañeta, Ryan F. Donnelly, Niamh McGoldrick, Katarzyna Migalska, Maeliosa T.C. McCrudden, Nicola J. Irwin, Louise Donnelly, Colin P. McCoy

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66 Citations (Scopus)
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Abstract

We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in ?on-demand? delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.
Original languageEnglish
Pages (from-to)907-914
Number of pages8
JournalMolecular Pharmaceutics
Volume13
Issue number3
Early online date21 Jan 2016
DOIs
Publication statusPublished - 07 Mar 2016

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