Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

John G. Hardy; Eneko Larrañeta; Ryan F. Donnelly; Niamh McGoldrick; Katarzyna Migalska; Maeliosa T.C. McCrudden; Nicola J. Irwin; Louise Donnelly; Colin P. McCoy

doi:10.1021/acs.molpharmaceut.5b00807

Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

John G. Hardy, Eneko Larrañeta, Ryan F. Donnelly, Niamh McGoldrick, Katarzyna Migalska, Maeliosa T.C. McCrudden, Nicola J. Irwin, Louise Donnelly, Colin P. McCoy

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Abstract

We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in ?on-demand? delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

Original language	English
Pages (from-to)	907-914
Number of pages	8
Journal	Molecular Pharmaceutics
Volume	13
Issue number	3
Early online date	21 Jan 2016
DOIs	https://doi.org/10.1021/acs.molpharmaceut.5b00807
Publication status	Published - 07 Mar 2016

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Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery
© 2016 American Chemical Society This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5b00807
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Colin McCoy
- C.McCoyqub.acuk
- School of Pharmacy - Dean of the Graduate School
- Material and Advanced Technologies for Healthcare
Person: Academic

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@article{013af2643cad4374b7add41b2fb6083d,

title = "Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery",

abstract = "We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in ?on-demand? delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.",

author = "Hardy, {John G.} and Eneko Larra{\~n}eta and Donnelly, {Ryan F.} and Niamh McGoldrick and Katarzyna Migalska and McCrudden, {Maeliosa T.C.} and Irwin, {Nicola J.} and Louise Donnelly and McCoy, {Colin P.}",

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doi = "10.1021/acs.molpharmaceut.5b00807",

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T1 - Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

AU - Hardy, John G.

AU - Larrañeta, Eneko

AU - Donnelly, Ryan F.

AU - McGoldrick, Niamh

AU - Migalska, Katarzyna

AU - McCrudden, Maeliosa T.C.

AU - Irwin, Nicola J.

AU - Donnelly, Louise

AU - McCoy, Colin P.

PY - 2016/3/7

Y1 - 2016/3/7

N2 - We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in ?on-demand? delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

AB - We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in ?on-demand? delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

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JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

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Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

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