Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

L. Li, M. Bhatia, Y.Z. Zhu, Y.C. Zhu, R.D. Ramnath, Z.J. Wang, F.B.M. Anuar, M. Whiteman, Manuel Salto-Tellez, P.K. Moore

Research output: Contribution to journalArticlepeer-review

617 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S) is synthesized in the body from L-Cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 +/- 0.7 mu M to 40.9 +/- 0.6 mu M (n=6, P
Original languageEnglish
Pages (from-to)1196
Number of pages1
JournalThe FASEB Journal
Volume19
Issue number9
DOIs
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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