Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

L. Li; M. Bhatia; Y.Z. Zhu; Y.C. Zhu; R.D. Ramnath; Z.J. Wang; F.B.M. Anuar; M. Whiteman; Manuel Salto-Tellez; P.K. Moore

doi:10.1096/fj.04-3583fje

Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

L. Li, M. Bhatia, Y.Z. Zhu, Y.C. Zhu, R.D. Ramnath, Z.J. Wang, F.B.M. Anuar, M. Whiteman, Manuel Salto-Tellez, P.K. Moore

Research output: Contribution to journal › Article › peer-review

617 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S) is synthesized in the body from L-Cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 +/- 0.7 mu M to 40.9 +/- 0.6 mu M (n=6, P

Original language	English
Pages (from-to)	1196
Number of pages	1
Journal	The FASEB Journal
Volume	19
Issue number	9
DOIs	https://doi.org/10.1096/fj.04-3583fje
Publication status	Published - Jul 2005

ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Cell Biology

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title = "Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse",

abstract = "Hydrogen sulfide (H2S) is synthesized in the body from L-Cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 +/- 0.7 mu M to 40.9 +/- 0.6 mu M (n=6, P",

author = "L. Li and M. Bhatia and Y.Z. Zhu and Y.C. Zhu and R.D. Ramnath and Z.J. Wang and F.B.M. Anuar and M. Whiteman and Manuel Salto-Tellez and P.K. Moore",

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language = "English",

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TY - JOUR

T1 - Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

AU - Li, L.

AU - Bhatia, M.

AU - Zhu, Y.Z.

AU - Zhu, Y.C.

AU - Ramnath, R.D.

AU - Wang, Z.J.

AU - Anuar, F.B.M.

AU - Whiteman, M.

AU - Salto-Tellez, Manuel

AU - Moore, P.K.

PY - 2005/7

Y1 - 2005/7

N2 - Hydrogen sulfide (H2S) is synthesized in the body from L-Cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 +/- 0.7 mu M to 40.9 +/- 0.6 mu M (n=6, P

AB - Hydrogen sulfide (H2S) is synthesized in the body from L-Cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 +/- 0.7 mu M to 40.9 +/- 0.6 mu M (n=6, P

U2 - 10.1096/fj.04-3583fje

DO - 10.1096/fj.04-3583fje

M3 - Article

VL - 19

SP - 1196

JO - The FASEB Journal

JF - The FASEB Journal

SN - 0892-6638

IS - 9

ER -