Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications

Tanya Levingstone*, Badriah Ali, Cathal Kearney, Nicholas Dunne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

While bones have the innate capability to physiologically regenerate, in certain cases regeneration is suboptimal, too slow, or does not occur. Biomaterials‐based growth factor delivery systems have shown potential for the treatment of challenging bone defects, however, achieving controlled growth factor release remains a challenge. The objective of this study was to develop a thermally responsive hydrogel for bone regeneration capable of ultrasound‐triggered on‐demand delivery of therapeutic agents. Furthermore, it was hypothesized that incorporation of hydroxyapatite (HA) into the hydrogel could increase sonosensitization, augmenting ultrasound sensitivity to enable controlled therapeutic release to the target tissue. Alginate thermally responsive P(Alg‐g‐NIPAAm) hydrogels were fabricated and varying quantities of HA (1, 3, 5, and 7% wt./vol.) incorporated. All hydrogels were highly injectable (maximum injection force below 6.5 N) and rheological characterization demonstrated their ability to gel at body temperature. The study demonstrated the ultrasound‐triggered release of sodium fluorescein (NaF), bovine serum albumin (BSA), and bone morphogenetic protein 2 (BMP‐2) from the hydrogels. Release rates of BSA and BMP‐2 were significantly enhanced in the HA containing hydrogels, confirming for the first time the role of HA as a son sensitizer. Together these results demonstrate the potential of these ultrasound‐triggered thermally responsive hydrogels for on‐demand delivery of therapeutic agents for bone regeneration.
Original languageEnglish
Pages (from-to)1622-1633
Number of pages12
JournalJournal of Biomedical Materials Research - Part B: Applied Biomaterials
Volume109
Issue number10
Early online date18 Feb 2021
DOIs
Publication statusEarly online date - 18 Feb 2021

Keywords

  • ORIGINAL RESEARCH REPORT
  • ORIGINAL RESEARCH REPORTS
  • bone
  • controlled delivery
  • hydrogel
  • thermally responsive
  • ultrasound

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