Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism

D. O'Toole, P. Hassett, M. Contreras, B.D. Higgins, Scott McKeown, Danny McAuley, T. O'Brien, J.G. Laffey

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)

Abstract

Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.
Original languageEnglish
Pages (from-to)976-982
Number of pages7
JournalThorax
Volume64
Issue number11
DOIs
Publication statusPublished - Nov 2009

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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