Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
O'Toole, D., Hassett, P., Contreras, M., Higgins, B. D., McKeown, S., McAuley, D., O'Brien, T., & Laffey, J. G. (2009). Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism. Thorax, 64(11), 976-982. https://doi.org/10.1136/thx.2008.110304