Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism

D. O'Toole, P. Hassett, M. Contreras, B.D. Higgins, Scott McKeown, Danny McAuley, T. O'Brien, J.G. Laffey

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.
Original languageEnglish
Pages (from-to)976-982
Number of pages7
JournalThorax
Volume64
Issue number11
DOIs
Publication statusPublished - Nov 2009

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    O'Toole, D., Hassett, P., Contreras, M., Higgins, B. D., McKeown, S., McAuley, D., O'Brien, T., & Laffey, J. G. (2009). Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism. Thorax, 64(11), 976-982. https://doi.org/10.1136/thx.2008.110304