Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism

D. O'Toole; P. Hassett; M. Contreras; B.D. Higgins; Scott McKeown; Danny McAuley; T. O'Brien; J.G. Laffey

doi:10.1136/thx.2008.110304

Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism

D. O'Toole
, P. Hassett
, M. Contreras
, B.D. Higgins
, Scott McKeown
, Danny McAuley
, T. O'Brien
, J.G. Laffey

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.

Original language	English
Pages (from-to)	976-982
Number of pages	7
Journal	Thorax
Volume	64
Issue number	11
DOIs	https://doi.org/10.1136/thx.2008.110304
Publication status	Published - Nov 2009

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thx.2008.110304

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title = "Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism",

abstract = "Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.",

author = "D. O'Toole and P. Hassett and M. Contreras and B.D. Higgins and Scott McKeown and Danny McAuley and T. O'Brien and J.G. Laffey",

year = "2009",

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T1 - Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism

AU - O'Toole, D.

AU - Hassett, P.

AU - Contreras, M.

AU - Higgins, B.D.

AU - McKeown, Scott

AU - McAuley, Danny

AU - O'Brien, T.

AU - Laffey, J.G.

PY - 2009/11

Y1 - 2009/11

N2 - Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.

AB - Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional regulator in inflammation and repair.

UR - https://www.scopus.com/pages/publications/72549102010

U2 - 10.1136/thx.2008.110304

DO - 10.1136/thx.2008.110304

M3 - Article

SN - 0040-6376

VL - 64

SP - 976

EP - 982

JO - Thorax

JF - Thorax

IS - 11

ER -

Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism

Abstract

ASJC Scopus subject areas

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