Hyperglycemia and adverse pregnancy outcome (HAPO) study: Associations with neonatal anthropometrics

B.E. Metzger, L.P. Lowe, A.R. Dyer, E.R. Trimble, B. Sheridan, M. Hod, R. Chen, Y. Yogev, D.R. Coustan, P.M. Catalano, W. Giles, J. Lowe, D.R. Hadden, B. Persson, J.J.N. Oats

Research output: Contribution to journalArticle

473 Citations (Scopus)

Abstract

OBJECTIVE-To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS-Eligible pregnant women underwent a standard 75-g oral glucose tolerance test between 24 and 32 weeks gestation (as close to 28 weeks as possible). Neonatal anthropometrics and cord serum C-peptide were measured. Associations of maternal glucose and cord serum C-peptide with neonatal adiposity (sum of skin folds >90th percentile or percent body fat >90th percentile) were assessed using multiple logistic regression analyses, with adjustment for potential confounders, including maternal age, parity, BMI, mean arterial pressure, height, gestational age at delivery, and the baby's sex. RESULTS-Among 23,316 HAPO Study participants with glucose levels blinded to caregivers, cord serum C-peptide results were available for 19,885 babies and skin fold measurements for 19,389. For measures of neonatal adiposity, there were strong statistically significant gradients across increasing levels of maternal glucose and cord serum C-peptide, which persisted after adjustment for potential confounders. In fully adjusted continuous variable models, odds ratios ranged from 1.35 to 1.44 for the two measures of adiposity for fasting, 1-h, and 2-h plasma glucose higher by 1 SD. CONCLUSIONS-These findings confirm the link between maternal glucose and neonatal adiposity and suggest that the relationship is mediated by fetal insulin production and that the Pedersen hypothesis describes a basic biological relationship influencing fetal growth.
Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalDiabetes
Volume58
Issue number2
DOIs
Publication statusPublished - 01 Feb 2009

Fingerprint

Adiposity
Pregnancy Outcome
C-Peptide
Hyperglycemia
Outcome Assessment (Health Care)
Glucose
Mothers
Serum
Skin
Maternal Age
Hyperinsulinism
Glucose Tolerance Test
Fetal Development
Parity
Caregivers
Gestational Age
Multicenter Studies
Adipose Tissue
Pregnant Women
Fasting

Cite this

Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. R., Sheridan, B., Hod, M., ... Oats, J. J. N. (2009). Hyperglycemia and adverse pregnancy outcome (HAPO) study: Associations with neonatal anthropometrics. Diabetes, 58(2), 453-459. https://doi.org/10.2337/db08-1112
Metzger, B.E. ; Lowe, L.P. ; Dyer, A.R. ; Trimble, E.R. ; Sheridan, B. ; Hod, M. ; Chen, R. ; Yogev, Y. ; Coustan, D.R. ; Catalano, P.M. ; Giles, W. ; Lowe, J. ; Hadden, D.R. ; Persson, B. ; Oats, J.J.N. / Hyperglycemia and adverse pregnancy outcome (HAPO) study : Associations with neonatal anthropometrics. In: Diabetes. 2009 ; Vol. 58, No. 2. pp. 453-459.
@article{023a762430fa4e96b708392931addbed,
title = "Hyperglycemia and adverse pregnancy outcome (HAPO) study: Associations with neonatal anthropometrics",
abstract = "OBJECTIVE-To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS-Eligible pregnant women underwent a standard 75-g oral glucose tolerance test between 24 and 32 weeks gestation (as close to 28 weeks as possible). Neonatal anthropometrics and cord serum C-peptide were measured. Associations of maternal glucose and cord serum C-peptide with neonatal adiposity (sum of skin folds >90th percentile or percent body fat >90th percentile) were assessed using multiple logistic regression analyses, with adjustment for potential confounders, including maternal age, parity, BMI, mean arterial pressure, height, gestational age at delivery, and the baby's sex. RESULTS-Among 23,316 HAPO Study participants with glucose levels blinded to caregivers, cord serum C-peptide results were available for 19,885 babies and skin fold measurements for 19,389. For measures of neonatal adiposity, there were strong statistically significant gradients across increasing levels of maternal glucose and cord serum C-peptide, which persisted after adjustment for potential confounders. In fully adjusted continuous variable models, odds ratios ranged from 1.35 to 1.44 for the two measures of adiposity for fasting, 1-h, and 2-h plasma glucose higher by 1 SD. CONCLUSIONS-These findings confirm the link between maternal glucose and neonatal adiposity and suggest that the relationship is mediated by fetal insulin production and that the Pedersen hypothesis describes a basic biological relationship influencing fetal growth.",
author = "B.E. Metzger and L.P. Lowe and A.R. Dyer and E.R. Trimble and B. Sheridan and M. Hod and R. Chen and Y. Yogev and D.R. Coustan and P.M. Catalano and W. Giles and J. Lowe and D.R. Hadden and B. Persson and J.J.N. Oats",
year = "2009",
month = "2",
day = "1",
doi = "10.2337/db08-1112",
language = "English",
volume = "58",
pages = "453--459",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "2",

}

Metzger, BE, Lowe, LP, Dyer, AR, Trimble, ER, Sheridan, B, Hod, M, Chen, R, Yogev, Y, Coustan, DR, Catalano, PM, Giles, W, Lowe, J, Hadden, DR, Persson, B & Oats, JJN 2009, 'Hyperglycemia and adverse pregnancy outcome (HAPO) study: Associations with neonatal anthropometrics', Diabetes, vol. 58, no. 2, pp. 453-459. https://doi.org/10.2337/db08-1112

Hyperglycemia and adverse pregnancy outcome (HAPO) study : Associations with neonatal anthropometrics. / Metzger, B.E.; Lowe, L.P.; Dyer, A.R.; Trimble, E.R.; Sheridan, B.; Hod, M.; Chen, R.; Yogev, Y.; Coustan, D.R.; Catalano, P.M.; Giles, W.; Lowe, J.; Hadden, D.R.; Persson, B.; Oats, J.J.N.

In: Diabetes, Vol. 58, No. 2, 01.02.2009, p. 453-459.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hyperglycemia and adverse pregnancy outcome (HAPO) study

T2 - Associations with neonatal anthropometrics

AU - Metzger, B.E.

AU - Lowe, L.P.

AU - Dyer, A.R.

AU - Trimble, E.R.

AU - Sheridan, B.

AU - Hod, M.

AU - Chen, R.

AU - Yogev, Y.

AU - Coustan, D.R.

AU - Catalano, P.M.

AU - Giles, W.

AU - Lowe, J.

AU - Hadden, D.R.

AU - Persson, B.

AU - Oats, J.J.N.

PY - 2009/2/1

Y1 - 2009/2/1

N2 - OBJECTIVE-To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS-Eligible pregnant women underwent a standard 75-g oral glucose tolerance test between 24 and 32 weeks gestation (as close to 28 weeks as possible). Neonatal anthropometrics and cord serum C-peptide were measured. Associations of maternal glucose and cord serum C-peptide with neonatal adiposity (sum of skin folds >90th percentile or percent body fat >90th percentile) were assessed using multiple logistic regression analyses, with adjustment for potential confounders, including maternal age, parity, BMI, mean arterial pressure, height, gestational age at delivery, and the baby's sex. RESULTS-Among 23,316 HAPO Study participants with glucose levels blinded to caregivers, cord serum C-peptide results were available for 19,885 babies and skin fold measurements for 19,389. For measures of neonatal adiposity, there were strong statistically significant gradients across increasing levels of maternal glucose and cord serum C-peptide, which persisted after adjustment for potential confounders. In fully adjusted continuous variable models, odds ratios ranged from 1.35 to 1.44 for the two measures of adiposity for fasting, 1-h, and 2-h plasma glucose higher by 1 SD. CONCLUSIONS-These findings confirm the link between maternal glucose and neonatal adiposity and suggest that the relationship is mediated by fetal insulin production and that the Pedersen hypothesis describes a basic biological relationship influencing fetal growth.

AB - OBJECTIVE-To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS-Eligible pregnant women underwent a standard 75-g oral glucose tolerance test between 24 and 32 weeks gestation (as close to 28 weeks as possible). Neonatal anthropometrics and cord serum C-peptide were measured. Associations of maternal glucose and cord serum C-peptide with neonatal adiposity (sum of skin folds >90th percentile or percent body fat >90th percentile) were assessed using multiple logistic regression analyses, with adjustment for potential confounders, including maternal age, parity, BMI, mean arterial pressure, height, gestational age at delivery, and the baby's sex. RESULTS-Among 23,316 HAPO Study participants with glucose levels blinded to caregivers, cord serum C-peptide results were available for 19,885 babies and skin fold measurements for 19,389. For measures of neonatal adiposity, there were strong statistically significant gradients across increasing levels of maternal glucose and cord serum C-peptide, which persisted after adjustment for potential confounders. In fully adjusted continuous variable models, odds ratios ranged from 1.35 to 1.44 for the two measures of adiposity for fasting, 1-h, and 2-h plasma glucose higher by 1 SD. CONCLUSIONS-These findings confirm the link between maternal glucose and neonatal adiposity and suggest that the relationship is mediated by fetal insulin production and that the Pedersen hypothesis describes a basic biological relationship influencing fetal growth.

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-63249084929&md5=9b88e25c5ca3c93d922fd3442c45627a

U2 - 10.2337/db08-1112

DO - 10.2337/db08-1112

M3 - Article

AN - SCOPUS:63249084929

VL - 58

SP - 453

EP - 459

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 2

ER -