Hyperglycemia and adverse pregnancy outcome study: Neonatal glycemia

B.E. Metzger, L.P. Lowe, A.R. Dyer, B. Persson, J.K. Cruickshank, C. Deerochanawong, H.L. Halliday, E.R. Trimble, A.J. Hennis, H. Liley, P.C. Ng, D.R. Coustan, D.R. Hadden, M. Hod, J.J.N. Oats

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The goal was to describe the temporal pattern of neonatal plasma glucose levels and associations with maternal glucose levels, cord serum C-peptide levels, and neonatal size and adiposity. METHODS: A total of 17 094 mothers and infants were included in the Hyperglycemia and Adverse Pregnancy Outcome Study (15 centers in 9 countries). Mothers underwent a 75-g, 2-hour, oral glucose tolerance test (OGTT) at 24 to 32 weeks of gestation. Cord blood and neonatal blood samples were collected. Biochemical neonatal hypoglycemia was defined as glucose levels of 90th percentile. CONCLUSIONS: Mean neonatal plasma glucose concentrations varied little in the first 5 hours after birth, which suggests normal postnatal adjustment. Biochemical and clinical hypoglycemia were weakly related to maternal OGTT glucose measurements but were strongly associated with elevated cord serum C-peptide levels. Larger and/or fatter infants were more likely to develop hypoglycemia and hyperinsulinemia. These relationships suggest physiologic relationships between maternal glycemia and fetal insulin production.
Original languageEnglish
JournalPediatrics
Volume126
Issue number6
DOIs
Publication statusPublished - 01 Dec 2010

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Pregnancy Outcome
Hyperglycemia
Mothers
Outcome Assessment (Health Care)
Glucose
Hypoglycemia
C-Peptide
Glucose Tolerance Test
Social Adjustment
Adiposity
Hyperinsulinism
Serum
Fetal Blood
Fats
Parturition
Insulin
Pregnancy

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Metzger, B. E., Lowe, L. P., Dyer, A. R., Persson, B., Cruickshank, J. K., Deerochanawong, C., ... Oats, J. J. N. (2010). Hyperglycemia and adverse pregnancy outcome study: Neonatal glycemia. Pediatrics, 126(6). https://doi.org/10.1542/peds.2009-2257
Metzger, B.E. ; Lowe, L.P. ; Dyer, A.R. ; Persson, B. ; Cruickshank, J.K. ; Deerochanawong, C. ; Halliday, H.L. ; Trimble, E.R. ; Hennis, A.J. ; Liley, H. ; Ng, P.C. ; Coustan, D.R. ; Hadden, D.R. ; Hod, M. ; Oats, J.J.N. / Hyperglycemia and adverse pregnancy outcome study : Neonatal glycemia. In: Pediatrics. 2010 ; Vol. 126, No. 6.
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Metzger, BE, Lowe, LP, Dyer, AR, Persson, B, Cruickshank, JK, Deerochanawong, C, Halliday, HL, Trimble, ER, Hennis, AJ, Liley, H, Ng, PC, Coustan, DR, Hadden, DR, Hod, M & Oats, JJN 2010, 'Hyperglycemia and adverse pregnancy outcome study: Neonatal glycemia', Pediatrics, vol. 126, no. 6. https://doi.org/10.1542/peds.2009-2257

Hyperglycemia and adverse pregnancy outcome study : Neonatal glycemia. / Metzger, B.E.; Lowe, L.P.; Dyer, A.R.; Persson, B.; Cruickshank, J.K.; Deerochanawong, C.; Halliday, H.L.; Trimble, E.R.; Hennis, A.J.; Liley, H.; Ng, P.C.; Coustan, D.R.; Hadden, D.R.; Hod, M.; Oats, J.J.N.

In: Pediatrics, Vol. 126, No. 6, 01.12.2010.

Research output: Contribution to journalArticle

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T1 - Hyperglycemia and adverse pregnancy outcome study

T2 - Neonatal glycemia

AU - Metzger, B.E.

AU - Lowe, L.P.

AU - Dyer, A.R.

AU - Persson, B.

AU - Cruickshank, J.K.

AU - Deerochanawong, C.

AU - Halliday, H.L.

AU - Trimble, E.R.

AU - Hennis, A.J.

AU - Liley, H.

AU - Ng, P.C.

AU - Coustan, D.R.

AU - Hadden, D.R.

AU - Hod, M.

AU - Oats, J.J.N.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - OBJECTIVE: The goal was to describe the temporal pattern of neonatal plasma glucose levels and associations with maternal glucose levels, cord serum C-peptide levels, and neonatal size and adiposity. METHODS: A total of 17 094 mothers and infants were included in the Hyperglycemia and Adverse Pregnancy Outcome Study (15 centers in 9 countries). Mothers underwent a 75-g, 2-hour, oral glucose tolerance test (OGTT) at 24 to 32 weeks of gestation. Cord blood and neonatal blood samples were collected. Biochemical neonatal hypoglycemia was defined as glucose levels of 90th percentile. CONCLUSIONS: Mean neonatal plasma glucose concentrations varied little in the first 5 hours after birth, which suggests normal postnatal adjustment. Biochemical and clinical hypoglycemia were weakly related to maternal OGTT glucose measurements but were strongly associated with elevated cord serum C-peptide levels. Larger and/or fatter infants were more likely to develop hypoglycemia and hyperinsulinemia. These relationships suggest physiologic relationships between maternal glycemia and fetal insulin production.

AB - OBJECTIVE: The goal was to describe the temporal pattern of neonatal plasma glucose levels and associations with maternal glucose levels, cord serum C-peptide levels, and neonatal size and adiposity. METHODS: A total of 17 094 mothers and infants were included in the Hyperglycemia and Adverse Pregnancy Outcome Study (15 centers in 9 countries). Mothers underwent a 75-g, 2-hour, oral glucose tolerance test (OGTT) at 24 to 32 weeks of gestation. Cord blood and neonatal blood samples were collected. Biochemical neonatal hypoglycemia was defined as glucose levels of 90th percentile. CONCLUSIONS: Mean neonatal plasma glucose concentrations varied little in the first 5 hours after birth, which suggests normal postnatal adjustment. Biochemical and clinical hypoglycemia were weakly related to maternal OGTT glucose measurements but were strongly associated with elevated cord serum C-peptide levels. Larger and/or fatter infants were more likely to develop hypoglycemia and hyperinsulinemia. These relationships suggest physiologic relationships between maternal glycemia and fetal insulin production.

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Metzger BE, Lowe LP, Dyer AR, Persson B, Cruickshank JK, Deerochanawong C et al. Hyperglycemia and adverse pregnancy outcome study: Neonatal glycemia. Pediatrics. 2010 Dec 1;126(6). https://doi.org/10.1542/peds.2009-2257