Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification

Ingrid J. Guldvik*, Verena Zuber, Peder R. Braadland, Helene H. Grytli, Håkon Ramberg, Wolfgang Lilleby, Bernd Thiede, Manuela Zucknick, Fahri Saatcioglu, Randi Gislefoss, Rune Kvåle, Anne George, Henrik Grönberg, Fredrik Wiklund, David E. Neal, Vincent J. Gnanapragasam, Kristin A. Taskén, Ian G. Mills

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
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Abstract

High blood levels of leucine-rich α-2-glycoprotein 1 (LRG1) is unfavourable in patients with newly diagnosed high-risk or metastatic prostate cancer. Implementation of a blood test for LRG1 alongside standard risk stratification schemes could provide higher precision in treatment decisions.

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalEuropean Urology Open Science
Volume21
DOIs
Publication statusPublished - 13 Oct 2020

Bibliographical note

Funding Information:
Funding/Support and role of the sponsor: This work has been supported by the Anders Jahre Foundation , University of Oslo , Movember Foundation , South-Eastern Norway Regional Health Authority , Oslo University Hospital , and the Norwegian Research Council , whereas the urology biorepository for the ProMPT (Prostate Cancer Mechanisms of Progression and Treatment) study is funded by the CRUK Cambridge Centre urology malignancy programme and the Cambridge NIHR Biomedical Campus.

Publisher Copyright:
© 2020 The Author(s)

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Biomarker
  • Leucine-rich α-2-glycoprotein 1
  • Noninvasive
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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