Abstract
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
Original language | English |
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Pages (from-to) | 1055-7 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 41 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2009 |
Keywords
- Chromosomes, Human, Pair 8
- Disease Susceptibility
- European Continental Ancestry Group
- Genetic Markers
- Genome, Human
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Polymorphism, Single Nucleotide
- Prostatic Neoplasms
- Risk Factors
- Journal Article
- Research Support, N.I.H., Extramural