Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager; Nilanjan Chatterjee; Julia Ciampa; Kevin B Jacobs; Jesus Gonzalez-Bosquet; Richard B Hayes; Peter Kraft; Sholom Wacholder; Nick Orr; Sonja I Berndt; Kai Yu; Amy Hutchinson; Zhaoming Wang; Laufey Amundadottir; Heather Spencer Feigelson; Michael J Thun; W Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R. Schumacher; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Christopher A. Haiman; Brian Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Timothy J Key; Rudolf Kaaks; William Isaacs; Sarah Isaacs; Kathleen E Wiley; Henrik Gronberg; Fredrik Wiklund; Pär Stattin; Jianfeng Xu; S Lilly Zheng; Jielin Sun; Lars J Vatten; Kristian Hveem; Merethe Kumle; Margaret Tucker; Daniela S Gerhard; Robert N Hoover; Joseph F Fraumeni; David J Hunter; Gilles Thomas; Stephen J.  Chanock

doi:10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja I Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J Thun, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie WeinsteinFredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Christopher A. Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S Lilly Zheng, Jielin Sun, Lars J Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S Gerhard, Robert N Hoover, Joseph F Fraumeni, David J Hunter, Gilles Thomas, Stephen J. Chanock

Research output: Contribution to journal › Article › peer-review

189 Citations (Scopus)

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original language	English
Pages (from-to)	1055-7
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1038/ng.444
Publication status	Published - Oct 2009

Keywords

Chromosomes, Human, Pair 8
Disease Susceptibility
European Continental Ancestry Group
Genetic Markers
Genome, Human
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Risk Factors
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.444

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Yeager, M., Chatterjee, N., Ciampa, J., Jacobs, K. B., Gonzalez-Bosquet, J., Hayes, R. B., Kraft, P., Wacholder, S., Orr, N., Berndt, S. I., Yu, K., Hutchinson, A., Wang, Z., Amundadottir, L., Feigelson, H. S., Thun, M. J., Diver, W. R., Albanes, D., Virtamo, J., ... Chanock, S. J. (2009). Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature Genetics, 41(10), 1055-7. https://doi.org/10.1038/ng.444

Yeager, Meredith ; Chatterjee, Nilanjan ; Ciampa, Julia ; Jacobs, Kevin B ; Gonzalez-Bosquet, Jesus ; Hayes, Richard B ; Kraft, Peter ; Wacholder, Sholom ; Orr, Nick ; Berndt, Sonja I ; Yu, Kai ; Hutchinson, Amy ; Wang, Zhaoming ; Amundadottir, Laufey ; Feigelson, Heather Spencer ; Thun, Michael J ; Diver, W Ryan ; Albanes, Demetrius ; Virtamo, Jarmo ; Weinstein, Stephanie ; Schumacher, Fredrick R. ; Cancel-Tassin, Geraldine ; Cussenot, Olivier ; Valeri, Antoine ; Andriole, Gerald L ; Crawford, E David ; Haiman, Christopher A. ; Henderson, Brian ; Kolonel, Laurence ; Le Marchand, Loic ; Siddiq, Afshan ; Riboli, Elio ; Key, Timothy J ; Kaaks, Rudolf ; Isaacs, William ; Isaacs, Sarah ; Wiley, Kathleen E ; Gronberg, Henrik ; Wiklund, Fredrik ; Stattin, Pär ; Xu, Jianfeng ; Zheng, S Lilly ; Sun, Jielin ; Vatten, Lars J ; Hveem, Kristian ; Kumle, Merethe ; Tucker, Margaret ; Gerhard, Daniela S ; Hoover, Robert N ; Fraumeni, Joseph F ; Hunter, David J ; Thomas, Gilles ; Chanock, Stephen J. . / Identification of a new prostate cancer susceptibility locus on chromosome 8q24. In: Nature Genetics. 2009 ; Vol. 41, No. 10. pp. 1055-7.

@article{96adc425897045d0bf83f6d5f1b6d7b5,

title = "Identification of a new prostate cancer susceptibility locus on chromosome 8q24",

abstract = "We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.",

keywords = "Chromosomes, Human, Pair 8, Disease Susceptibility, European Continental Ancestry Group, Genetic Markers, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors, Journal Article, Research Support, N.I.H., Extramural",

author = "Meredith Yeager and Nilanjan Chatterjee and Julia Ciampa and Jacobs, {Kevin B} and Jesus Gonzalez-Bosquet and Hayes, {Richard B} and Peter Kraft and Sholom Wacholder and Nick Orr and Berndt, {Sonja I} and Kai Yu and Amy Hutchinson and Zhaoming Wang and Laufey Amundadottir and Feigelson, {Heather Spencer} and Thun, {Michael J} and Diver, {W Ryan} and Demetrius Albanes and Jarmo Virtamo and Stephanie Weinstein and Schumacher, {Fredrick R.} and Geraldine Cancel-Tassin and Olivier Cussenot and Antoine Valeri and Andriole, {Gerald L} and Crawford, {E David} and Haiman, {Christopher A.} and Brian Henderson and Laurence Kolonel and {Le Marchand}, Loic and Afshan Siddiq and Elio Riboli and Key, {Timothy J} and Rudolf Kaaks and William Isaacs and Sarah Isaacs and Wiley, {Kathleen E} and Henrik Gronberg and Fredrik Wiklund and P{\"a}r Stattin and Jianfeng Xu and Zheng, {S Lilly} and Jielin Sun and Vatten, {Lars J} and Kristian Hveem and Merethe Kumle and Margaret Tucker and Gerhard, {Daniela S} and Hoover, {Robert N} and Fraumeni, {Joseph F} and Hunter, {David J} and Gilles Thomas and Chanock, {Stephen J.}",

year = "2009",

month = oct,

doi = "10.1038/ng.444",

language = "English",

volume = "41",

pages = "1055--7",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

Yeager, M, Chatterjee, N, Ciampa, J, Jacobs, KB, Gonzalez-Bosquet, J, Hayes, RB, Kraft, P, Wacholder, S, Orr, N, Berndt, SI, Yu, K, Hutchinson, A, Wang, Z, Amundadottir, L, Feigelson, HS, Thun, MJ, Diver, WR, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, FR, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, GL, Crawford, ED, Haiman, CA, Henderson, B, Kolonel, L, Le Marchand, L, Siddiq, A, Riboli, E, Key, TJ, Kaaks, R, Isaacs, W, Isaacs, S, Wiley, KE, Gronberg, H, Wiklund, F, Stattin, P, Xu, J, Zheng, SL, Sun, J, Vatten, LJ, Hveem, K, Kumle, M, Tucker, M, Gerhard, DS, Hoover, RN, Fraumeni, JF, Hunter, DJ, Thomas, G & Chanock, SJ 2009, 'Identification of a new prostate cancer susceptibility locus on chromosome 8q24', Nature Genetics, vol. 41, no. 10, pp. 1055-7. https://doi.org/10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24. / Yeager, Meredith; Chatterjee, Nilanjan; Ciampa, Julia; Jacobs, Kevin B; Gonzalez-Bosquet, Jesus; Hayes, Richard B; Kraft, Peter; Wacholder, Sholom; Orr, Nick; Berndt, Sonja I; Yu, Kai; Hutchinson, Amy; Wang, Zhaoming; Amundadottir, Laufey; Feigelson, Heather Spencer; Thun, Michael J; Diver, W Ryan; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Schumacher, Fredrick R.; Cancel-Tassin, Geraldine; Cussenot, Olivier; Valeri, Antoine; Andriole, Gerald L; Crawford, E David; Haiman, Christopher A.; Henderson, Brian; Kolonel, Laurence; Le Marchand, Loic; Siddiq, Afshan; Riboli, Elio; Key, Timothy J; Kaaks, Rudolf; Isaacs, William; Isaacs, Sarah; Wiley, Kathleen E; Gronberg, Henrik; Wiklund, Fredrik; Stattin, Pär; Xu, Jianfeng; Zheng, S Lilly; Sun, Jielin; Vatten, Lars J; Hveem, Kristian; Kumle, Merethe; Tucker, Margaret; Gerhard, Daniela S; Hoover, Robert N; Fraumeni, Joseph F; Hunter, David J; Thomas, Gilles; Chanock, Stephen J. .

In: Nature Genetics, Vol. 41, No. 10, 10.2009, p. 1055-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Identification of a new prostate cancer susceptibility locus on chromosome 8q24

AU - Yeager, Meredith

AU - Chatterjee, Nilanjan

AU - Ciampa, Julia

AU - Jacobs, Kevin B

AU - Gonzalez-Bosquet, Jesus

AU - Hayes, Richard B

AU - Kraft, Peter

AU - Wacholder, Sholom

AU - Orr, Nick

AU - Berndt, Sonja I

AU - Yu, Kai

AU - Hutchinson, Amy

AU - Wang, Zhaoming

AU - Amundadottir, Laufey

AU - Feigelson, Heather Spencer

AU - Thun, Michael J

AU - Diver, W Ryan

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Weinstein, Stephanie

AU - Schumacher, Fredrick R.

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Valeri, Antoine

AU - Andriole, Gerald L

AU - Crawford, E David

AU - Haiman, Christopher A.

AU - Henderson, Brian

AU - Kolonel, Laurence

AU - Le Marchand, Loic

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Key, Timothy J

AU - Kaaks, Rudolf

AU - Isaacs, William

AU - Isaacs, Sarah

AU - Wiley, Kathleen E

AU - Gronberg, Henrik

AU - Wiklund, Fredrik

AU - Stattin, Pär

AU - Xu, Jianfeng

AU - Zheng, S Lilly

AU - Sun, Jielin

AU - Vatten, Lars J

AU - Hveem, Kristian

AU - Kumle, Merethe

AU - Tucker, Margaret

AU - Gerhard, Daniela S

AU - Hoover, Robert N

AU - Fraumeni, Joseph F

AU - Hunter, David J

AU - Thomas, Gilles

AU - Chanock, Stephen J.

PY - 2009/10

Y1 - 2009/10

N2 - We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

AB - We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

KW - Chromosomes, Human, Pair 8

KW - Disease Susceptibility

KW - European Continental Ancestry Group

KW - Genetic Markers

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

KW - Risk Factors

KW - Journal Article

KW - Research Support, N.I.H., Extramural

U2 - 10.1038/ng.444

DO - 10.1038/ng.444

M3 - Article

C2 - 19767755

VL - 41

SP - 1055

EP - 1057

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Abstract

Keywords

UN SDGs

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