Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager; Nilanjan Chatterjee; Julia Ciampa; Kevin B Jacobs; Jesus Gonzalez-Bosquet; Richard B Hayes; Peter Kraft; Sholom Wacholder; Nick Orr; Sonja I Berndt; Kai Yu; Amy Hutchinson; Zhaoming Wang; Laufey Amundadottir; Heather Spencer Feigelson; Michael J Thun; W Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R. Schumacher; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Christopher A. Haiman; Brian Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Timothy J Key; Rudolf Kaaks; William Isaacs; Sarah Isaacs; Kathleen E Wiley; Henrik Gronberg; Fredrik Wiklund; Pär Stattin; Jianfeng Xu; S Lilly Zheng; Jielin Sun; Lars J Vatten; Kristian Hveem; Merethe Kumle; Margaret Tucker; Daniela S Gerhard; Robert N Hoover; Joseph F Fraumeni; David J Hunter; Gilles Thomas; Stephen J.  Chanock

doi:10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja I Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J Thun, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie WeinsteinFredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Christopher A. Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S Lilly Zheng, Jielin Sun, Lars J Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S Gerhard, Robert N Hoover, Joseph F Fraumeni, David J Hunter, Gilles Thomas, Stephen J. Chanock

Research output: Contribution to journal › Article › peer-review

185 Citations (Scopus)

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original language	English
Pages (from-to)	1055-7
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1038/ng.444
Publication status	Published - Oct 2009

Keywords

Chromosomes, Human, Pair 8
Disease Susceptibility
European Continental Ancestry Group
Genetic Markers
Genome, Human
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Risk Factors
Journal Article
Research Support, N.I.H., Extramural

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Yeager, M., Chatterjee, N., Ciampa, J., Jacobs, K. B., Gonzalez-Bosquet, J., Hayes, R. B., Kraft, P., Wacholder, S., Orr, N., Berndt, S. I., Yu, K., Hutchinson, A., Wang, Z., Amundadottir, L., Feigelson, H. S., Thun, M. J., Diver, W. R., Albanes, D., Virtamo, J., ... Chanock, S. J. (2009). Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature Genetics, 41(10), 1055-7. https://doi.org/10.1038/ng.444

Yeager, Meredith ; Chatterjee, Nilanjan ; Ciampa, Julia ; Jacobs, Kevin B ; Gonzalez-Bosquet, Jesus ; Hayes, Richard B ; Kraft, Peter ; Wacholder, Sholom ; Orr, Nick ; Berndt, Sonja I ; Yu, Kai ; Hutchinson, Amy ; Wang, Zhaoming ; Amundadottir, Laufey ; Feigelson, Heather Spencer ; Thun, Michael J ; Diver, W Ryan ; Albanes, Demetrius ; Virtamo, Jarmo ; Weinstein, Stephanie ; Schumacher, Fredrick R. ; Cancel-Tassin, Geraldine ; Cussenot, Olivier ; Valeri, Antoine ; Andriole, Gerald L ; Crawford, E David ; Haiman, Christopher A. ; Henderson, Brian ; Kolonel, Laurence ; Le Marchand, Loic ; Siddiq, Afshan ; Riboli, Elio ; Key, Timothy J ; Kaaks, Rudolf ; Isaacs, William ; Isaacs, Sarah ; Wiley, Kathleen E ; Gronberg, Henrik ; Wiklund, Fredrik ; Stattin, Pär ; Xu, Jianfeng ; Zheng, S Lilly ; Sun, Jielin ; Vatten, Lars J ; Hveem, Kristian ; Kumle, Merethe ; Tucker, Margaret ; Gerhard, Daniela S ; Hoover, Robert N ; Fraumeni, Joseph F ; Hunter, David J ; Thomas, Gilles ; Chanock, Stephen J. . / Identification of a new prostate cancer susceptibility locus on chromosome 8q24. In: Nature Genetics. 2009 ; Vol. 41, No. 10. pp. 1055-7.

@article{96adc425897045d0bf83f6d5f1b6d7b5,

title = "Identification of a new prostate cancer susceptibility locus on chromosome 8q24",

abstract = "We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.",

keywords = "Chromosomes, Human, Pair 8, Disease Susceptibility, European Continental Ancestry Group, Genetic Markers, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors, Journal Article, Research Support, N.I.H., Extramural",

author = "Meredith Yeager and Nilanjan Chatterjee and Julia Ciampa and Jacobs, {Kevin B} and Jesus Gonzalez-Bosquet and Hayes, {Richard B} and Peter Kraft and Sholom Wacholder and Nick Orr and Berndt, {Sonja I} and Kai Yu and Amy Hutchinson and Zhaoming Wang and Laufey Amundadottir and Feigelson, {Heather Spencer} and Thun, {Michael J} and Diver, {W Ryan} and Demetrius Albanes and Jarmo Virtamo and Stephanie Weinstein and Schumacher, {Fredrick R.} and Geraldine Cancel-Tassin and Olivier Cussenot and Antoine Valeri and Andriole, {Gerald L} and Crawford, {E David} and Haiman, {Christopher A.} and Brian Henderson and Laurence Kolonel and {Le Marchand}, Loic and Afshan Siddiq and Elio Riboli and Key, {Timothy J} and Rudolf Kaaks and William Isaacs and Sarah Isaacs and Wiley, {Kathleen E} and Henrik Gronberg and Fredrik Wiklund and P{\"a}r Stattin and Jianfeng Xu and Zheng, {S Lilly} and Jielin Sun and Vatten, {Lars J} and Kristian Hveem and Merethe Kumle and Margaret Tucker and Gerhard, {Daniela S} and Hoover, {Robert N} and Fraumeni, {Joseph F} and Hunter, {David J} and Gilles Thomas and Chanock, {Stephen J.}",

year = "2009",

month = oct,

doi = "10.1038/ng.444",

language = "English",

volume = "41",

pages = "1055--7",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

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Yeager, M, Chatterjee, N, Ciampa, J, Jacobs, KB, Gonzalez-Bosquet, J, Hayes, RB, Kraft, P, Wacholder, S, Orr, N, Berndt, SI, Yu, K, Hutchinson, A, Wang, Z, Amundadottir, L, Feigelson, HS, Thun, MJ, Diver, WR, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, FR, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, GL, Crawford, ED, Haiman, CA, Henderson, B, Kolonel, L, Le Marchand, L, Siddiq, A, Riboli, E, Key, TJ, Kaaks, R, Isaacs, W, Isaacs, S, Wiley, KE, Gronberg, H, Wiklund, F, Stattin, P, Xu, J, Zheng, SL, Sun, J, Vatten, LJ, Hveem, K, Kumle, M, Tucker, M, Gerhard, DS, Hoover, RN, Fraumeni, JF, Hunter, DJ, Thomas, G & Chanock, SJ 2009, 'Identification of a new prostate cancer susceptibility locus on chromosome 8q24', Nature Genetics, vol. 41, no. 10, pp. 1055-7. https://doi.org/10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24. / Yeager, Meredith; Chatterjee, Nilanjan; Ciampa, Julia; Jacobs, Kevin B; Gonzalez-Bosquet, Jesus; Hayes, Richard B; Kraft, Peter; Wacholder, Sholom; Orr, Nick; Berndt, Sonja I; Yu, Kai; Hutchinson, Amy; Wang, Zhaoming; Amundadottir, Laufey; Feigelson, Heather Spencer; Thun, Michael J; Diver, W Ryan; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Schumacher, Fredrick R.; Cancel-Tassin, Geraldine; Cussenot, Olivier; Valeri, Antoine; Andriole, Gerald L; Crawford, E David; Haiman, Christopher A.; Henderson, Brian; Kolonel, Laurence; Le Marchand, Loic; Siddiq, Afshan; Riboli, Elio; Key, Timothy J; Kaaks, Rudolf; Isaacs, William; Isaacs, Sarah; Wiley, Kathleen E; Gronberg, Henrik; Wiklund, Fredrik; Stattin, Pär; Xu, Jianfeng; Zheng, S Lilly; Sun, Jielin; Vatten, Lars J; Hveem, Kristian; Kumle, Merethe; Tucker, Margaret; Gerhard, Daniela S; Hoover, Robert N; Fraumeni, Joseph F; Hunter, David J; Thomas, Gilles; Chanock, Stephen J. .

In: Nature Genetics, Vol. 41, No. 10, 10.2009, p. 1055-7.

Research output: Contribution to journal › Article › peer-review

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AU - Chatterjee, Nilanjan

AU - Ciampa, Julia

AU - Jacobs, Kevin B

AU - Gonzalez-Bosquet, Jesus

AU - Hayes, Richard B

AU - Kraft, Peter

AU - Wacholder, Sholom

AU - Orr, Nick

AU - Berndt, Sonja I

AU - Yu, Kai

AU - Hutchinson, Amy

AU - Wang, Zhaoming

AU - Amundadottir, Laufey

AU - Feigelson, Heather Spencer

AU - Thun, Michael J

AU - Diver, W Ryan

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Weinstein, Stephanie

AU - Schumacher, Fredrick R.

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Valeri, Antoine

AU - Andriole, Gerald L

AU - Crawford, E David

AU - Haiman, Christopher A.

AU - Henderson, Brian

AU - Kolonel, Laurence

AU - Le Marchand, Loic

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Key, Timothy J

AU - Kaaks, Rudolf

AU - Isaacs, William

AU - Isaacs, Sarah

AU - Wiley, Kathleen E

AU - Gronberg, Henrik

AU - Wiklund, Fredrik

AU - Stattin, Pär

AU - Xu, Jianfeng

AU - Zheng, S Lilly

AU - Sun, Jielin

AU - Vatten, Lars J

AU - Hveem, Kristian

AU - Kumle, Merethe

AU - Tucker, Margaret

AU - Gerhard, Daniela S

AU - Hoover, Robert N

AU - Fraumeni, Joseph F

AU - Hunter, David J

AU - Thomas, Gilles

AU - Chanock, Stephen J.

PY - 2009/10

Y1 - 2009/10

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AB - We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

KW - Chromosomes, Human, Pair 8

KW - Disease Susceptibility

KW - European Continental Ancestry Group

KW - Genetic Markers

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

KW - Risk Factors

KW - Journal Article

KW - Research Support, N.I.H., Extramural

U2 - 10.1038/ng.444

DO - 10.1038/ng.444

M3 - Article

C2 - 19767755

VL - 41

SP - 1055

EP - 1057

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -