Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja I Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J Thun, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie WeinsteinFredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Christopher A. Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S Lilly Zheng, Jielin Sun, Lars J Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S Gerhard, Robert N Hoover, Joseph F Fraumeni, David J Hunter, Gilles Thomas, Stephen J. Chanock

Research output: Contribution to journalArticlepeer-review

185 Citations (Scopus)

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original languageEnglish
Pages (from-to)1055-7
Number of pages3
JournalNature Genetics
Volume41
Issue number10
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Chromosomes, Human, Pair 8
  • Disease Susceptibility
  • European Continental Ancestry Group
  • Genetic Markers
  • Genome, Human
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms
  • Risk Factors
  • Journal Article
  • Research Support, N.I.H., Extramural

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