Identification of MRP-8 (calgranulin A) as a major responsive protein in chronic periodontitis

Fionnuala Lundy, R. Chalk, Philip Lamey, Christopher Shaw, Gerard Linden

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22 Citations (Scopus)


The purpose of the study was to analyse how the protein composition of the inflammatory exudate associated with chronic periodontitis differed from the exudate in periodontal health. Gingival crevicular fluid (GCF) was collected from sites with chronic periodontal inflammation and from non-diseased sites in healthy control subjects. Microbore HPLC analysis revealed one major difference in GCF protein profiles between healthy controls and periodontitis patients. The protein enhanced in periodontitis patients was identified as migration inhibitory factor-related protein-8 (MRP-8) by a combination of N-terminal amino acid sequencing, mass spectrometry, and SDS-PAGE. Together, these data demonstrate, for the first time, the presence of monomeric MRP-8 in an inflammatory exudate. Whether monomeric MRP-8 is a unique feature of chronic periodontal inflammation is not yet clear, but the chemotactic properties of this peptide support a functional role for MRP-8 in periodontal inflammation. Copyright (C) 2000 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)540-544
Number of pages5
JournalJournal of Pathology
Volume192 (4)
Issue number4
Publication statusPublished - Dec 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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