Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry

Karine Redeuil; Candice Smarrito-Menozzi; Philippe Guy; Serge Rezzi; F. Dionisi; Gary Williamson; Kornél Nagy; M. Renouf

doi:10.1016/j.chroma.2011.05.050

Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry

Karine Redeuil
, Candice Smarrito-Menozzi
, Philippe Guy
, Serge Rezzi
, F. Dionisi
, Gary Williamson
, Kornél Nagy
, M. Renouf

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

This study reports a liquid chromatography-mass spectrometry method for the detection of polyphenol-derived metabolites in human plasma without enzymatic treatment after coffee consumption. Separation of available standards was achieved by reversed-phase ultra performance liquid chromatography and detection was performed by high resolution mass spectrometry in negative electrospray ionization mode. This analytical method was then applied for the identification and relative quantification of circulating coffee metabolites. A total of 34 coffee metabolites (mainly reduced, sulfated and methylated forms of caffeic acid, coumaric acid, caffeoylquinic acid and caffeoylquinic acid lactone) were identified based on mass accuracy (

Original language	English
Pages (from-to)	4678-4688
Number of pages	11
Journal	Journal of Chromatography A
Volume	1218
Issue number	29
Early online date	26 May 2011
DOIs	https://doi.org/10.1016/j.chroma.2011.05.050
Publication status	Published - 22 Jul 2011
Externally published	Yes

Bibliographical note

DA - 20110628 IS - 1873-3778 (Electronic) IS - 0021-9673 (Linking) LA - eng PT - Journal Article RN - 0 (Cinnamates) RN - 0 (Coffee) RN - 0 (Glucuronides) RN - 0 (Hydroxybenzoic Acids) RN - 0 (caffeoylquinic acid) RN - 77-95-2 (Quinic Acid) SB - IM

Keywords

ACID ACIDS Adult analogs & derivatives BIOAVAILABILITY Biological Availability blood CAFFEIC ACID Chromatography,High Pressure Liquid Cinnamates Coffee CONSUMPTION Female FORMS glucuronide Glucuronides Human HUMAN PLASMA HUMANS Hydroxybenzoic Acids IDENTIFICATION LIQUID-CHROMATOGRAPHY Male Mass Spectrometry metabolism METABOLITES Metabolomics methods PLASMA polyphenol QUANTIFICATION Quinic Acid RESOLUTION SEPARATION Spectrometry,Mass,Electrospray Ionization TIME

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title = "Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry",

abstract = "This study reports a liquid chromatography-mass spectrometry method for the detection of polyphenol-derived metabolites in human plasma without enzymatic treatment after coffee consumption. Separation of available standards was achieved by reversed-phase ultra performance liquid chromatography and detection was performed by high resolution mass spectrometry in negative electrospray ionization mode. This analytical method was then applied for the identification and relative quantification of circulating coffee metabolites. A total of 34 coffee metabolites (mainly reduced, sulfated and methylated forms of caffeic acid, coumaric acid, caffeoylquinic acid and caffeoylquinic acid lactone) were identified based on mass accuracy (",

keywords = "ACID ACIDS Adult analogs \& derivatives BIOAVAILABILITY Biological Availability blood CAFFEIC ACID Chromatography,High Pressure Liquid Cinnamates Coffee CONSUMPTION Female FORMS glucuronide Glucuronides Human HUMAN PLASMA HUMANS Hydroxybenzoic Acids IDENTIFICATION LIQUID-CHROMATOGRAPHY Male Mass Spectrometry metabolism METABOLITES Metabolomics methods PLASMA polyphenol QUANTIFICATION Quinic Acid RESOLUTION SEPARATION Spectrometry,Mass,Electrospray Ionization TIME",

author = "Karine Redeuil and Candice Smarrito-Menozzi and Philippe Guy and Serge Rezzi and F. Dionisi and Gary Williamson and Korn{\'e}l Nagy and M. Renouf",

note = "DA - 20110628 IS - 1873-3778 (Electronic) IS - 0021-9673 (Linking) LA - eng PT - Journal Article RN - 0 (Cinnamates) RN - 0 (Coffee) RN - 0 (Glucuronides) RN - 0 (Hydroxybenzoic Acids) RN - 0 (caffeoylquinic acid) RN - 77-95-2 (Quinic Acid) SB - IM",

year = "2011",

month = jul,

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doi = "10.1016/j.chroma.2011.05.050",

language = "English",

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T1 - Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry

AU - Redeuil, Karine

AU - Smarrito-Menozzi, Candice

AU - Guy, Philippe

AU - Rezzi, Serge

AU - Dionisi, F.

AU - Williamson, Gary

AU - Nagy, Kornél

AU - Renouf, M.

N1 - DA - 20110628 IS - 1873-3778 (Electronic) IS - 0021-9673 (Linking) LA - eng PT - Journal Article RN - 0 (Cinnamates) RN - 0 (Coffee) RN - 0 (Glucuronides) RN - 0 (Hydroxybenzoic Acids) RN - 0 (caffeoylquinic acid) RN - 77-95-2 (Quinic Acid) SB - IM

PY - 2011/7/22

Y1 - 2011/7/22

N2 - This study reports a liquid chromatography-mass spectrometry method for the detection of polyphenol-derived metabolites in human plasma without enzymatic treatment after coffee consumption. Separation of available standards was achieved by reversed-phase ultra performance liquid chromatography and detection was performed by high resolution mass spectrometry in negative electrospray ionization mode. This analytical method was then applied for the identification and relative quantification of circulating coffee metabolites. A total of 34 coffee metabolites (mainly reduced, sulfated and methylated forms of caffeic acid, coumaric acid, caffeoylquinic acid and caffeoylquinic acid lactone) were identified based on mass accuracy (

AB - This study reports a liquid chromatography-mass spectrometry method for the detection of polyphenol-derived metabolites in human plasma without enzymatic treatment after coffee consumption. Separation of available standards was achieved by reversed-phase ultra performance liquid chromatography and detection was performed by high resolution mass spectrometry in negative electrospray ionization mode. This analytical method was then applied for the identification and relative quantification of circulating coffee metabolites. A total of 34 coffee metabolites (mainly reduced, sulfated and methylated forms of caffeic acid, coumaric acid, caffeoylquinic acid and caffeoylquinic acid lactone) were identified based on mass accuracy (

KW - ACID ACIDS Adult analogs & derivatives BIOAVAILABILITY Biological Availability blood CAFFEIC ACID Chromatography,High Pressure Liquid Cinnamates Coffee CONSUMPTION Female FORMS glucuronide Glucuronides Human HUMAN PLASMA HUMANS Hydroxybenzoic Acids IDENTI

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DO - 10.1016/j.chroma.2011.05.050

M3 - Article

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VL - 1218

SP - 4678

EP - 4688

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 29

ER -

Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry

Abstract

Bibliographical note

Keywords

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