Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages

Muneo Yamaguchi; Shintaro Nakao; Iori Wada; Tetsuya Matoba; Mitsuru Arima; Yoshihiro Kaizu; Mariko Shirane; Keijiro Ishikawa; Takahito Nakama; Yusuke Murakami; Masaharu Mizuochi; Wataru Shiraishi; Ryo Yamasaki; Toshio Hisatomi; Tatsuro Ishibashi; Masabumi Shibuya; Alan W. Stitt; Koh-Hei Sonoda

doi:10.2337/db21-0247

Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages

Muneo Yamaguchi, Shintaro Nakao, Iori Wada, Tetsuya Matoba, Mitsuru Arima, Yoshihiro Kaizu, Mariko Shirane, Keijiro Ishikawa, Takahito Nakama, Yusuke Murakami, Masaharu Mizuochi, Wataru Shiraishi, Ryo Yamasaki, Toshio Hisatomi, Tatsuro Ishibashi, Masabumi Shibuya, Alan W. Stitt, Koh-Hei Sonoda

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Intraretinal hyperreflective foci (HRF) are significant biomarkers for diabetic macular edema. However, HRF at the vitreoretinal interface (VRI) have not been examined in diabetic retinopathy (DR). A prospective observational clinical study with 162 consecutive eyes using OCT imaging showed significantly increased HRF at the VRI during DR progression (P

Original language	English
Pages (from-to)	2685-2701
Journal	Diabetes
Volume	71
Issue number	12
Early online date	06 Oct 2022
DOIs	https://doi.org/10.2337/db21-0247
Publication status	Early online date - 06 Oct 2022

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Yamaguchi, M., Nakao, S., Wada, I., Matoba, T., Arima, M., Kaizu, Y., Shirane, M., Ishikawa, K., Nakama, T., Murakami, Y., Mizuochi, M., Shiraishi, W., Yamasaki, R., Hisatomi, T., Ishibashi, T., Shibuya, M., Stitt, A. W., & Sonoda, K.-H. (2022). Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages. Diabetes, 71(12), 2685-2701. Advance online publication. https://doi.org/10.2337/db21-0247

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title = "Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages",

abstract = "Intraretinal hyperreflective foci (HRF) are significant biomarkers for diabetic macular edema. However, HRF at the vitreoretinal interface (VRI) have not been examined in diabetic retinopathy (DR). A prospective observational clinical study with 162 consecutive eyes using OCT imaging showed significantly increased HRF at the VRI during DR progression (P ",

author = "Muneo Yamaguchi and Shintaro Nakao and Iori Wada and Tetsuya Matoba and Mitsuru Arima and Yoshihiro Kaizu and Mariko Shirane and Keijiro Ishikawa and Takahito Nakama and Yusuke Murakami and Masaharu Mizuochi and Wataru Shiraishi and Ryo Yamasaki and Toshio Hisatomi and Tatsuro Ishibashi and Masabumi Shibuya and Stitt, \{Alan W.\} and Koh-Hei Sonoda",

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Yamaguchi, M, Nakao, S, Wada, I, Matoba, T, Arima, M, Kaizu, Y, Shirane, M, Ishikawa, K, Nakama, T, Murakami, Y, Mizuochi, M, Shiraishi, W, Yamasaki, R, Hisatomi, T, Ishibashi, T, Shibuya, M, Stitt, AW & Sonoda, K-H 2022, 'Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages', Diabetes, vol. 71, no. 12, pp. 2685-2701. https://doi.org/10.2337/db21-0247

TY - JOUR

T1 - Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages

AU - Yamaguchi, Muneo

AU - Nakao, Shintaro

AU - Wada, Iori

AU - Matoba, Tetsuya

AU - Arima, Mitsuru

AU - Kaizu, Yoshihiro

AU - Shirane, Mariko

AU - Ishikawa, Keijiro

AU - Nakama, Takahito

AU - Murakami, Yusuke

AU - Mizuochi, Masaharu

AU - Shiraishi, Wataru

AU - Yamasaki, Ryo

AU - Hisatomi, Toshio

AU - Ishibashi, Tatsuro

AU - Shibuya, Masabumi

AU - Stitt, Alan W.

AU - Sonoda, Koh-Hei

PY - 2022/10/6

Y1 - 2022/10/6

N2 - Intraretinal hyperreflective foci (HRF) are significant biomarkers for diabetic macular edema. However, HRF at the vitreoretinal interface (VRI) have not been examined in diabetic retinopathy (DR). A prospective observational clinical study with 162 consecutive eyes using OCT imaging showed significantly increased HRF at the VRI during DR progression (P

AB - Intraretinal hyperreflective foci (HRF) are significant biomarkers for diabetic macular edema. However, HRF at the vitreoretinal interface (VRI) have not been examined in diabetic retinopathy (DR). A prospective observational clinical study with 162 consecutive eyes using OCT imaging showed significantly increased HRF at the VRI during DR progression (P

U2 - 10.2337/db21-0247

DO - 10.2337/db21-0247

M3 - Article

C2 - 36203331

SN - 0012-1797

VL - 71

SP - 2685

EP - 2701

JO - Diabetes

JF - Diabetes

IS - 12

ER -

Identifying hyperreflective foci in diabetic retinopathy via VEGF-induced local self-renewal of CX3CR1+ vitreous resident macrophages

Abstract

Bibliographical note

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