Identifying research priorities for cognition in CKD. A Delphi study

Jamie Alexiuk; Oksana Harasemiw; Jessica Vanderlinden; Davide Verrelli; Brett Tarca; David Collister; Heitor Ribeiro; Bonnie Corradetti; Kevin Fowler; Fabio Manfredini; Mara Mcadams-Demarco; Nadia Chu; Shilpa Jesudason; Clare Mckeaveney; Silvia J. Leon; Urmila Anandh; James Tollitt; Stephanie Thompson; Indranil Dasgupta; Clara Bohm

doi:10.34067/KID.0000000708

Identifying research priorities for cognition in CKD. A Delphi study

Jamie Alexiuk, Oksana Harasemiw, Jessica Vanderlinden, Davide Verrelli, Brett Tarca, David Collister, Heitor Ribeiro, Bonnie Corradetti, Kevin Fowler, Fabio Manfredini, Mara Mcadams-Demarco, Nadia Chu, Shilpa Jesudason, Clare Mckeaveney, Silvia J. Leon, Urmila Anandh, James Tollitt, Stephanie Thompson, Indranil Dasgupta, Clara Bohm^*

^*Corresponding author for this work

School of Nursing and Midwifery

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders.

Methods: A modified Delphi technique with 3 survey rounds was used. The study sample included 3 panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through REDCap. In Round 1 (October 2021-May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in Round 2 (Feb-April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the 'lived experience' panel were re-ranked in Round 3 (Aug-Sept 2023) and assessed for consensus to identify the final list of priority research questions.

Results: Respondents (n=152) identified 125 and 44 discrete questions after Rounds 1 and 2, respectively. The final shortlist included 27 questions in 8 categories. The most critical research question identified was "What factors prevent cognitive impairment in people receiving dialysis?" Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment.

Conclusions: Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.

Original language	English
Journal	Kidney360
Early online date	25 Jan 2025
DOIs	https://doi.org/10.34067/KID.0000000708
Publication status	Early online date - 25 Jan 2025

Keywords

cognition in CKD
CKD
Delphi study

ASJC Scopus subject areas

Nephrology
Medicine (miscellaneous)

Access to Document

10.34067/KID.0000000708Licence: CC BY-NC-ND

Cite this

Alexiuk, J., Harasemiw, O., Vanderlinden, J., Verrelli, D., Tarca, B., Collister, D., Ribeiro, H., Corradetti, B., Fowler, K., Manfredini, F., Mcadams-Demarco, M., Chu, N., Jesudason, S., Mckeaveney, C., Leon, S. J., Anandh, U., Tollitt, J., Thompson, S., Dasgupta, I., & Bohm, C. (2025). Identifying research priorities for cognition in CKD. A Delphi study. Kidney360. Advance online publication. https://doi.org/10.34067/KID.0000000708

@article{a5e858ecdfd54cfcbf51255f515180dc,

title = "Identifying research priorities for cognition in CKD. A Delphi study",

abstract = "Background: Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders. Methods: A modified Delphi technique with 3 survey rounds was used. The study sample included 3 panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through REDCap. In Round 1 (October 2021-May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in Round 2 (Feb-April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the 'lived experience' panel were re-ranked in Round 3 (Aug-Sept 2023) and assessed for consensus to identify the final list of priority research questions. Results: Respondents (n=152) identified 125 and 44 discrete questions after Rounds 1 and 2, respectively. The final shortlist included 27 questions in 8 categories. The most critical research question identified was {"}What factors prevent cognitive impairment in people receiving dialysis?{"} Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment. Conclusions: Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.",

keywords = "cognition in CKD, CKD, Delphi study",

author = "Jamie Alexiuk and Oksana Harasemiw and Jessica Vanderlinden and Davide Verrelli and Brett Tarca and David Collister and Heitor Ribeiro and Bonnie Corradetti and Kevin Fowler and Fabio Manfredini and Mara Mcadams-Demarco and Nadia Chu and Shilpa Jesudason and Clare Mckeaveney and Leon, {Silvia J.} and Urmila Anandh and James Tollitt and Stephanie Thompson and Indranil Dasgupta and Clara Bohm",

year = "2025",

month = jan,

day = "25",

doi = "10.34067/KID.0000000708",

language = "English",

journal = "Kidney360",

issn = "2641-7650",

publisher = "Kluwer Law International B.V.",

}

Alexiuk, J, Harasemiw, O, Vanderlinden, J, Verrelli, D, Tarca, B, Collister, D, Ribeiro, H, Corradetti, B, Fowler, K, Manfredini, F, Mcadams-Demarco, M, Chu, N, Jesudason, S, Mckeaveney, C, Leon, SJ, Anandh, U, Tollitt, J, Thompson, S, Dasgupta, I & Bohm, C 2025, 'Identifying research priorities for cognition in CKD. A Delphi study', Kidney360. https://doi.org/10.34067/KID.0000000708

TY - JOUR

T1 - Identifying research priorities for cognition in CKD. A Delphi study

AU - Alexiuk, Jamie

AU - Harasemiw, Oksana

AU - Vanderlinden, Jessica

AU - Verrelli, Davide

AU - Tarca, Brett

AU - Collister, David

AU - Ribeiro, Heitor

AU - Corradetti, Bonnie

AU - Fowler, Kevin

AU - Manfredini, Fabio

AU - Mcadams-Demarco, Mara

AU - Chu, Nadia

AU - Jesudason, Shilpa

AU - Mckeaveney, Clare

AU - Leon, Silvia J.

AU - Anandh, Urmila

AU - Tollitt, James

AU - Thompson, Stephanie

AU - Dasgupta, Indranil

AU - Bohm, Clara

PY - 2025/1/25

Y1 - 2025/1/25

N2 - Background: Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders. Methods: A modified Delphi technique with 3 survey rounds was used. The study sample included 3 panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through REDCap. In Round 1 (October 2021-May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in Round 2 (Feb-April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the 'lived experience' panel were re-ranked in Round 3 (Aug-Sept 2023) and assessed for consensus to identify the final list of priority research questions. Results: Respondents (n=152) identified 125 and 44 discrete questions after Rounds 1 and 2, respectively. The final shortlist included 27 questions in 8 categories. The most critical research question identified was "What factors prevent cognitive impairment in people receiving dialysis?" Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment. Conclusions: Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.

AB - Background: Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders. Methods: A modified Delphi technique with 3 survey rounds was used. The study sample included 3 panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through REDCap. In Round 1 (October 2021-May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in Round 2 (Feb-April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the 'lived experience' panel were re-ranked in Round 3 (Aug-Sept 2023) and assessed for consensus to identify the final list of priority research questions. Results: Respondents (n=152) identified 125 and 44 discrete questions after Rounds 1 and 2, respectively. The final shortlist included 27 questions in 8 categories. The most critical research question identified was "What factors prevent cognitive impairment in people receiving dialysis?" Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment. Conclusions: Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.

KW - cognition in CKD

KW - CKD

KW - Delphi study

U2 - 10.34067/KID.0000000708

DO - 10.34067/KID.0000000708

M3 - Article

AN - SCOPUS:85216993794

SN - 2641-7650

JO - Kidney360

JF - Kidney360

ER -

Identifying research priorities for cognition in CKD. A Delphi study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this