IgE glycosylation and impact on structure and function: A systematic review

Alexandra J. McCraw, Lais C. G. F. Palhares, Jenifer L. Hendel, Richard A. Gardner, Aida Santaolalla, Silvia Crescioli, James McDonnell, Mieke Van Hemelrijck, Alicia Chenoweth, Daniel I. R. Spencer, Gerd K. Wagner, Sophia N. Karagiannis

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
11 Downloads (Pure)

Abstract

The impact of human IgE glycosylation on structure, function and disease mechanisms is not fully elucidated, and heterogeneity in different studies renders drawing conclusions challenging. Previous reviews discussed IgE glycosylation focusing on specific topics such as health versus disease, FcεR binding or impact on function. We present the first systematic review of human IgE glycosylation conducted utilizing the PRISMA guidelines. We sought to define the current consensus concerning the roles of glycosylation on structure, biology and disease. Despite diverse analytical methodologies, source, expression systems and the sparsity of data on IgE antibodies from non‐allergic individuals, collectively evidence suggests differential glycosylation profiles, particularly in allergic diseases compared with healthy states, and indicates functional impact, and contributions to IgE‐mediated hypersensitivities and atopic diseases. Beyond allergic diseases, dysregulated terminal glycan structures, including sialic acid, may regulate IgE metabolism. Glycan sites such as N394 may contribute to stabilizing IgE structure, with alterations in these glycans likely influencing both structure and IgE‐FcεR interactions. This systematic review therefore highlights critical IgE glycosylation attributes in health and disease that may be exploitable for therapeutic intervention, and the need for novel analytics to explore pertinent research avenues.
Original languageEnglish
JournalAllergy
Early online date04 Aug 2024
DOIs
Publication statusEarly online date - 04 Aug 2024

Fingerprint

Dive into the research topics of 'IgE glycosylation and impact on structure and function: A systematic review'. Together they form a unique fingerprint.

Cite this