IGF-Binding Protein 2 - Oncogene or Tumor Suppressor?

Adam Pickard, Dennis J McCance

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)
195 Downloads (Pure)


The role of insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general, IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports in vitro and in vivo where IGFBP2 acts in a tumor suppressor manner. In this mini-review, we discuss the factors influencing the variation in IGFBP2 expression in cancer and our interpretation of these findings.
Original languageEnglish
Pages (from-to)25
JournalFrontiers in endocrinology
Issue number25
Early online date27 Feb 2015
Publication statusPublished - Feb 2015


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