Aims-An increased concentration of insulin-like growth factor 1 (IGF-1) is an independent risk factor for premenopausal breast cancer. Tamoxifen is thought initially to reduce concentrations of IGF-1 and increase concentrations of the IGF binding proteins. The aim of this study was to compare concentrations of IGF-1, IGF binding protein 1 (IGF-BP1), and IGF-BP3 in patients with breast cancer (n = 14) with those seen in control subjects (n = 23) and to assess the effect of tamoxifen on IGF status in these patients.
|Number of pages||4|
|Journal||JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY|
|Publication status||Published - 2001|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Campbell, M., Woodside, J., Secker-Walker, J., Titcomb, A., & Leathem, C. (2001). IGF status is altered by tamoxifen in patients with breast cancer. JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 54(5), 307-310.