IL-15 in autoimmunity and cancer O-tu-b or not O-tu-b?

Paul N. Moynagh*

*Corresponding author for this work

Research output: Contribution to journalComment/debate


The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.

Original languageEnglish
Pages (from-to)780-782
Number of pages3
JournalNature Immunology
Issue number7
Publication statusPublished - 10 Jun 2019


Cite this