IL-15 in autoimmunity and cancer O-tu-b or not O-tu-b?

Paul N. Moynagh*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.

Original languageEnglish
Pages (from-to)780-782
Number of pages3
JournalNature Immunology
Volume20
Issue number7
DOIs
Publication statusPublished - 10 Jun 2019

Fingerprint

Interleukin-15
Autoimmunity
Natural Killer Cells
Immunity
Neoplasms
Homeostasis
Cytokines
T-Lymphocytes
Deubiquitinating Enzymes

Cite this

@article{e63580b6f3064c31bd2475bcffa8a4b7,
title = "IL-15 in autoimmunity and cancer O-tu-b or not O-tu-b?",
abstract = "The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.",
author = "Moynagh, {Paul N.}",
year = "2019",
month = "6",
day = "10",
doi = "10.1038/s41590-019-0424-z",
language = "English",
volume = "20",
pages = "780--782",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "7",

}

IL-15 in autoimmunity and cancer O-tu-b or not O-tu-b? / Moynagh, Paul N.

In: Nature Immunology, Vol. 20, No. 7, 10.06.2019, p. 780-782.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - IL-15 in autoimmunity and cancer O-tu-b or not O-tu-b?

AU - Moynagh, Paul N.

PY - 2019/6/10

Y1 - 2019/6/10

N2 - The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.

AB - The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.

UR - http://www.scopus.com/inward/record.url?scp=85067288499&partnerID=8YFLogxK

U2 - 10.1038/s41590-019-0424-z

DO - 10.1038/s41590-019-0424-z

M3 - Comment/debate

C2 - 31182806

AN - SCOPUS:85067288499

VL - 20

SP - 780

EP - 782

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 7

ER -