Imaging intracellular and systemic in vivo gold nanoparticles to enhance radiotherapy

Stanley Walter Botchway , Jonathan A. Coulter, Frederick J. Currell

Research output: Contribution to journalArticle

14 Citations (Scopus)
116 Downloads (Pure)

Abstract

Nanoparticles offer alternative options in cancer therapy both as drug delivery carriers and as direct therapeutic agents for cancer cell inactivation. More recently, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers achieving significantly elevated radiation dose enhancement factors when irradiated with both kilo-electron-volt and mega-electronvolt X-rays. Use of AuNPs in radiobiology is now being intensely driven by the desire to achieve precise energy deposition in tumours. As a consequence, there is a growing demand for efficient and simple techniques for detection, imaging and characterization of AuNPs in both biological and tumour samples. Spatially accurate imaging on the nanoscale poses a serious challenge requiring high- or super-resolution imaging techniques. In this mini review, we discuss the challenges in using AuNPs as radiosensitizers as well as various current and novel imaging techniques designed to validate the uptake, distribution and localization in mammalian cells. In our own work, we have used multiphoton excited plasmon resonance imaging to map the AuNP intracellular distribution. The benefits and limitations of this approach will also be discussed in some detail. In some cases, the same "excitation" mechanism as is used in an imaging modality can be harnessed tomake it also a part of therapymodality (e.g. phototherapy)-such examples are discussed in passing as extensions to the imaging modality concerned.

Original languageEnglish
Article number20150170
Number of pages13
JournalBritish Journal of Radiology
Volume88
Issue number1054
Early online date24 Jul 2015
DOIs
Publication statusPublished - 01 Oct 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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