Imaging the genetics of executive function

C.M. Greene; W. Braet; Katherine Johnson; M.A. Bellgrove

doi:10.1016/j.biopsycho.2007.11.009

Imaging the genetics of executive function

C.M. Greene, W. Braet, Katherine Johnson, M.A. Bellgrove

School of Psychology

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Recent advances in neuroimaging technologies have allowed ever more detailed studies of the human brain. The combination of neuroimaging techniques with genetics may provide a more sensitive measure of the influence of genetic variants on cognitive function than behavioural measures alone. Here we present a review of functional magnetic resonance imaging (fMRI) studies of genetic links to executive functions, focusing on sustained attention, working memory and response inhibition. In addition to studies in the normal population, we also address findings from three clinical populations: schizophrenia, ADHD and autism spectrum disorders. While the findings in the populations studied do not always converge, they all point to the usefulness of neuroimaging techniques such as fMRI as potential endophenotypes for parsing the genetic aetiology of executive function. (C) 2007 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	30-42
Number of pages	13
Journal	Biological Psychology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/j.biopsycho.2007.11.009
Publication status	Published - Sept 2008

ASJC Scopus subject areas

Behavioral Neuroscience
Neuropsychology and Physiological Psychology

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10.1016/j.biopsycho.2007.11.009

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AB - Recent advances in neuroimaging technologies have allowed ever more detailed studies of the human brain. The combination of neuroimaging techniques with genetics may provide a more sensitive measure of the influence of genetic variants on cognitive function than behavioural measures alone. Here we present a review of functional magnetic resonance imaging (fMRI) studies of genetic links to executive functions, focusing on sustained attention, working memory and response inhibition. In addition to studies in the normal population, we also address findings from three clinical populations: schizophrenia, ADHD and autism spectrum disorders. While the findings in the populations studied do not always converge, they all point to the usefulness of neuroimaging techniques such as fMRI as potential endophenotypes for parsing the genetic aetiology of executive function. (C) 2007 Elsevier B.V. All rights reserved.

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Imaging the genetics of executive function

Abstract

ASJC Scopus subject areas

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