TY - JOUR
T1 - Immediate sequential changes in the tear film lipid layer following eyelid massage in dry eye syndrome: a comparative control study
AU - Chen, Jiayan
AU - Yu, Sile
AU - Qin, Guanghao
AU - Moutari, Salissou
AU - Moore, Jonathan E.
AU - Xu, Ling
AU - He, Wei
AU - Pazo, Emmanuel Eric
AU - He, Xingru
PY - 2024/8/20
Y1 - 2024/8/20
N2 - Background
/Purpose: Meibomian glands are sebaceous glands that release meibum onto the ocular surface; enhancing the quality and quantity of meibum secretions has been proven to improve signs and symptoms of evaporative dry eye (EDE) and meibomian gland dysfunction (MGD). This study aimed to evaluate and compare the efficacy of a heated eye mask (HEM) and eyelid massage device EyePeace (EP) in alleviating signs and symptoms of evaporative dry eye.
Methods
Forty dry eye participants were recruited in a prospective, contralateral-eye trial study. After undergoing 10 min of HEM therapy, eyelid massage therapy was applied to one eye by the device. The efficiency was assessed at four time points: baseline (0 mins), 5 minutes (5 mins), 15 minutes (15 mins), and 30 minutes (30 mins).. Non-invasive breakup time (NITBUT), redness score(RS Score), tear meniscus height (TMH), tear-film lipid layer (TFLL), endothelial cell count (ECC), meibomian gland expressibility (MGEx), meibomian gland quality (MGQ), conjunctivocorneal staining (CS), ocular surface temperature (OST), best corrected visual acuity (BCVA), intraocular pressure (IOP), central corneal thickness (CCT) flat-axis keratometry value (K1), and steep-axis keratometry value (K2), were examined.
Results
Baseline clinical measurements did not have statistically significant differences between the groups (all p > 0.05). After 30 minutes, a comparison was made between the HEM group and EP+HEM group, revealing significant changes only in the primary outcomes, TFLL (2.18±0.45 versus 2.40±0.50; p < 0.05), and MGEx grades (0.68±0.53 versus 0.98±0.70; p < 0.05). Improvements in NITBUT and TMH were sustained until 5 mins and 15 mins after using EP+HEM. No significant changes were observed in RS Score, MGQ, OST, CFS, BCVA, IOP, ECC, K1, K2, and CCT (all p > 0.05) at all test time points.
Conclusion
The application of a heated eye mask followed by a gentle massage using EyePeace on the eyelids can have a sustained improvement in the tear film lipid layer and meibomian gland expressivity score but not clinically significant, and does not pose any significant immediate impact on the cornea.
AB - Background
/Purpose: Meibomian glands are sebaceous glands that release meibum onto the ocular surface; enhancing the quality and quantity of meibum secretions has been proven to improve signs and symptoms of evaporative dry eye (EDE) and meibomian gland dysfunction (MGD). This study aimed to evaluate and compare the efficacy of a heated eye mask (HEM) and eyelid massage device EyePeace (EP) in alleviating signs and symptoms of evaporative dry eye.
Methods
Forty dry eye participants were recruited in a prospective, contralateral-eye trial study. After undergoing 10 min of HEM therapy, eyelid massage therapy was applied to one eye by the device. The efficiency was assessed at four time points: baseline (0 mins), 5 minutes (5 mins), 15 minutes (15 mins), and 30 minutes (30 mins).. Non-invasive breakup time (NITBUT), redness score(RS Score), tear meniscus height (TMH), tear-film lipid layer (TFLL), endothelial cell count (ECC), meibomian gland expressibility (MGEx), meibomian gland quality (MGQ), conjunctivocorneal staining (CS), ocular surface temperature (OST), best corrected visual acuity (BCVA), intraocular pressure (IOP), central corneal thickness (CCT) flat-axis keratometry value (K1), and steep-axis keratometry value (K2), were examined.
Results
Baseline clinical measurements did not have statistically significant differences between the groups (all p > 0.05). After 30 minutes, a comparison was made between the HEM group and EP+HEM group, revealing significant changes only in the primary outcomes, TFLL (2.18±0.45 versus 2.40±0.50; p < 0.05), and MGEx grades (0.68±0.53 versus 0.98±0.70; p < 0.05). Improvements in NITBUT and TMH were sustained until 5 mins and 15 mins after using EP+HEM. No significant changes were observed in RS Score, MGQ, OST, CFS, BCVA, IOP, ECC, K1, K2, and CCT (all p > 0.05) at all test time points.
Conclusion
The application of a heated eye mask followed by a gentle massage using EyePeace on the eyelids can have a sustained improvement in the tear film lipid layer and meibomian gland expressivity score but not clinically significant, and does not pose any significant immediate impact on the cornea.
U2 - 10.1016/j.heliyon.2024.e36590
DO - 10.1016/j.heliyon.2024.e36590
M3 - Article
SN - 2405-8440
JO - Heliyon
JF - Heliyon
M1 - e36590
ER -