Immunocytochemistry versus molecular fingerprinting of metastases

Manuel Salto-Tellez, D. Zhang, L.L. Chiu, S.C. Wang, B. Nilsson, E.S.C. Koay

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Examination of cytological samples of cancer to suggest a possible primary site of origin is one of the commonest and most difficult tasks of diagnostic cytopathologists. Currently, both cytomorphology and immunocytochemistry are the main approaches to this diagnostic dilemma. We report the application of microsatellite analysis in cytological samples in a patient with a primary colonic tumour and two subsequent lung nodules, which were suspected on CT scans of the chest, and compared the findings with those obtained with conventional immunocytochemistry. The molecular results were in agreement with the radiological impression and conflicted with the immunocytochemistry. We conclude that immunocytochemical and molecular biology approaches to the diagnosis of tumours may give rise to contradictory results.
Original languageEnglish
Pages (from-to)186-190
Number of pages5
Issue number4
Publication statusPublished - Aug 2003

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy


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