Immunoglobulin heavy chain sequence analysis in Waldenstrom's macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance.

R.A. Rollett, E.J. Wilkinson, D. Gonzalez, J.A. Fenton, M.A. Short, P.A. Evans, A.C. Rawstron, R.G. Owen

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8 Citations (Scopus)

Abstract

In this study, we used IGH sequence analysis to assess the maturational status of Waldenstrom's (WM) macroglobulinemia and its putative precursor immunoglobulin (Ig)-M monoclonal gammopathy of undetermined significance (MGUS). IGH sequence analysis was performed using standard methods in 23 cases (20 WM and 3 IgM MGUS as defined by consensus panel criteria). Waldenstrom's macroglobulinemia cases were characterized by heavily mutated IGH genes (median, 6.3%; range, 3.8%-13.9%) but without intraclonal variation (ICV). IgM MGUS was similarly characterized by somatic hypermutation (median, 7.5%; range, 7%-7.7%), but ICV was evident in 1 of the 3 cases. We would therefore conclude that WM is characterized by somatic hypermutation without ICV, which supports a derivation from postgerminal center/memory B cells. IgM MGUS is also characterized by somatic hypermutation but, in a manner similar to IgA/IgG MGUS, can be associated with ICV, although the significance of this remains unclear.
Original languageEnglish
Pages (from-to)70-72
Number of pages3
JournalCLINICAL LYMPHOMA & MYELOMA
Volume7
Issue number1
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Aged
  • Female
  • Gene Rearrangement
  • Humans
  • Immunoglobulin Heavy Chains
  • Immunoglobulin M
  • Male
  • Middle Aged
  • Mutation
  • Paraproteinemias
  • Sequence Analysis, DNA
  • Waldenstrom Macroglobulinemia

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