Immunohistochemistry in the era of personalised medicine

Clare Margaret McCourt, David Boyle, Jacqueline James, Manuel Salto-Tellez

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background

Immunohistochemistry (IHC) plays a central role in the histopathological classification of diseases, including cancer. More recently, the importance of immunohistochemical staining is increasing. IHC usage in diagnostics is invaluable; however, the genetic and therapeutic significance of biomarker immunostaining has become equally relevant.

Content

In this article, we would like to analyse the three distinct roles of IHC and review their individual impacts on modern diagnostic pathology: (1) diagnostic IHC; (2) genetic IHC and (3) therapeutic IHC.

Summary

Thus, we will characterise the different analytical processes that are required in the three approaches to IHC usage stated above, as well as the clinical significance and overall importance in patient management. This will allow us to hypothesise on the most appropriate laboratory environment and detection methods for the future.
Original languageEnglish
Pages (from-to)58-61
JournalJournal of Clinical Pathology
Volume66
Issue number1
Early online date23 Dec 2012
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Antineoplastic Agents
  • Pathology, Molecular
  • Receptor, erbB-2
  • Humans
  • Breast Neoplasms
  • Receptors, Steroid
  • Pathology, Surgical
  • Antibodies, Monoclonal
  • Laboratories, Hospital
  • Individualized Medicine
  • Lung Neoplasms
  • Tumor Markers, Biological
  • Carcinoma, Non-Small-Cell Lung
  • Immunohistochemistry
  • Female

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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