Immunolocalisation of the glutathione s-transferases, GST-26 and GST-28, within adult schistosoma japonicum

G. N. Gobert, D. J. Stenzel*, D. P. McManus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

This paper describes the first ultrastructural immunolocalisation study of the 26-kDa and 28-kDa glutathione S-transferases within adult Schistosoma japonicum (GST-26 and GST-28). Polyclonal antibodies raised against GST-28 (in mice) and against GST-26 (in rabbits) were used to examine the distribution of the proteins within adult parasites. Both proteins were localised within the parenchymal region of the male parasite. Additionally, both proteins were present within parenchymal cells located between the vitelline glands of female parasites. There were no detectable levels of GST-26 or GST-28 on the surface or within the tegument matrix of either the male or female worms. Possible functions for GST-26 and GST-28 within S. japonicum and their significance as vaccine target molecules are addressed.

Original languageEnglish
Pages (from-to)1437-1443
Number of pages7
JournalInternational Journal for Parasitology
Volume28
Issue number9
DOIs
Publication statusPublished - 01 Sep 1998
Externally publishedYes

Keywords

  • Glutathione S-transferase
  • Immunolocalisation
  • Schistosoma japonicum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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