Immunologically silent cancer clone transmission from mother to offspring

T. Isoda; A.M. Ford; D. Tomizawa; F.W. van Delft; D.G. de Castro; N. Mitsuiki; J. Score; T. Taki; T. Morio; M. Takagi; H. Saji; M. Greaves; S. Mizutani

doi:10.1073/pnas.0904658106

Immunologically silent cancer clone transmission from mother to offspring

T. Isoda, A.M. Ford, D. Tomizawa, F.W. van Delft, D.G. de Castro, N. Mitsuiki, J. Score, T. Taki, T. Morio, M. Takagi, H. Saji, M. Greaves, S. Mizutani

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally- derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.

Original language	English
Pages (from-to)	17882-17885
Number of pages	4
Journal	Proceedings of the National Academy of Sciences
Volume	106
Issue number	42
DOIs	https://doi.org/10.1073/pnas.0904658106
Publication status	Published - 20 Oct 2009

Keywords

fetus
fusion gene
leukemia
ACUTE LYMPHOBLASTIC-LEUKEMIA
TRANSPLACENTAL TRANSMISSION
CELL LYMPHOMA
CHROMOSOME
TUMOR
HLA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.0904658106

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title = "Immunologically silent cancer clone transmission from mother to offspring",

abstract = "Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally- derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.",

keywords = "fetus, fusion gene, leukemia, ACUTE LYMPHOBLASTIC-LEUKEMIA, TRANSPLACENTAL TRANSMISSION, CELL LYMPHOMA, CHROMOSOME, TUMOR, HLA",

author = "T. Isoda and A.M. Ford and D. Tomizawa and {van Delft}, F.W. and {de Castro}, D.G. and N. Mitsuiki and J. Score and T. Taki and T. Morio and M. Takagi and H. Saji and M. Greaves and S. Mizutani",

year = "2009",

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doi = "10.1073/pnas.0904658106",

language = "English",

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pages = "17882--17885",

journal = "Proceedings of the National Academy of Sciences",

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TY - JOUR

T1 - Immunologically silent cancer clone transmission from mother to offspring

AU - Isoda, T.

AU - Ford, A.M.

AU - Tomizawa, D.

AU - van Delft, F.W.

AU - de Castro, D.G.

AU - Mitsuiki, N.

AU - Score, J.

AU - Taki, T.

AU - Morio, T.

AU - Takagi, M.

AU - Saji, H.

AU - Greaves, M.

AU - Mizutani, S.

PY - 2009/10/20

Y1 - 2009/10/20

N2 - Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally- derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.

AB - Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally- derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.

KW - fetus

KW - fusion gene

KW - leukemia

KW - ACUTE LYMPHOBLASTIC-LEUKEMIA

KW - TRANSPLACENTAL TRANSMISSION

KW - CELL LYMPHOMA

KW - CHROMOSOME

KW - TUMOR

KW - HLA

U2 - 10.1073/pnas.0904658106

DO - 10.1073/pnas.0904658106

M3 - Article

SN - 0027-8424

VL - 106

SP - 17882

EP - 17885

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

IS - 42

ER -

Immunologically silent cancer clone transmission from mother to offspring

Abstract

Keywords

UN SDGs

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