Immunologically silent cancer clone transmission from mother to offspring

T. Isoda, A.M. Ford, D. Tomizawa, F.W. van Delft, D.G. de Castro, N. Mitsuiki, J. Score, T. Taki, T. Morio, M. Takagi, H. Saji, M. Greaves, S. Mizutani

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally- derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.
Original languageEnglish
Pages (from-to)17882-17885
Number of pages4
JournalProceedings of the National Academy of Sciences
Volume106
Issue number42
DOIs
Publication statusPublished - 20 Oct 2009

Keywords

  • fetus
  • fusion gene
  • leukemia
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • TRANSPLACENTAL TRANSMISSION
  • CELL LYMPHOMA
  • CHROMOSOME
  • TUMOR
  • HLA

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