TY - JOUR
T1 - Immunophenotypic shift in a case of mycosis fungoides with vitreous invasion
AU - Lois, N.
AU - Hiscott, P.S.
AU - Wong, D.
AU - Nash, J.
N1 - Medline is the source for the MeSH terms of this document.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The case of an 82-year-old man who developed intraocular extension from mycosis fungoides, a cutaneous T-cell lymphoma, is presented. The patient died soon after intra-ocular involvement occurred. Immunohistochemistry of a skin biopsy, taken early in the course of the disease, disclosed a predominance of T cells with a helper/inducer phenotype (CD4). However, an intraocular infiltrate obtained 7 years later contained mostly T cells with a suppressor/cytotoxic phenotype (CD8). The occurrence of ocular invasion, the change in immunophenotype, and the predominant proliferation of CD8 lymphocytes may have been related to the poor outcome in this patient.
AB - The case of an 82-year-old man who developed intraocular extension from mycosis fungoides, a cutaneous T-cell lymphoma, is presented. The patient died soon after intra-ocular involvement occurred. Immunohistochemistry of a skin biopsy, taken early in the course of the disease, disclosed a predominance of T cells with a helper/inducer phenotype (CD4). However, an intraocular infiltrate obtained 7 years later contained mostly T cells with a suppressor/cytotoxic phenotype (CD8). The occurrence of ocular invasion, the change in immunophenotype, and the predominant proliferation of CD8 lymphocytes may have been related to the poor outcome in this patient.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-0033673754&md5=9d288a7f30d187900a594c38cbe63317
M3 - Article
AN - SCOPUS:0033673754
SN - 0003-9950
VL - 118
SP - 1692
EP - 1694
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 12
ER -