Immunophenotypic shift in a case of mycosis fungoides with vitreous invasion

N. Lois, P.S. Hiscott, D. Wong, J. Nash

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19 Citations (Scopus)

Abstract

The case of an 82-year-old man who developed intraocular extension from mycosis fungoides, a cutaneous T-cell lymphoma, is presented. The patient died soon after intra-ocular involvement occurred. Immunohistochemistry of a skin biopsy, taken early in the course of the disease, disclosed a predominance of T cells with a helper/inducer phenotype (CD4). However, an intraocular infiltrate obtained 7 years later contained mostly T cells with a suppressor/cytotoxic phenotype (CD8). The occurrence of ocular invasion, the change in immunophenotype, and the predominant proliferation of CD8 lymphocytes may have been related to the poor outcome in this patient.
Original languageEnglish
Pages (from-to)1692-1694
Number of pages3
JournalArchives of Ophthalmology
Volume118
Issue number12
Publication statusPublished - 01 Jan 2000

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