Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project

Julie K K Vishram; Anders Borglykke; Anne H Andreasen; Jørgen Jeppesen; Hans Ibsen; Torben Jørgensen; Grazyna Broda; Luigi Palmieri; Simona Giampaoli; Chiara Donfrancesco; Frank Kee; Giuseppe Mancia; Giancarlo Cesana; Kari Kuulasmaa; Susana Sans; Michael H Olsen; On behalf of the MORGAM Project

doi:10.1161/HYPERTENSIONAHA.112.201400

Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project

Julie K K Vishram, Anders Borglykke, Anne H Andreasen, Jørgen Jeppesen, Hans Ibsen, Torben Jørgensen, Grazyna Broda, Luigi Palmieri, Simona Giampaoli, Chiara Donfrancesco, Frank Kee, Giuseppe Mancia, Giancarlo Cesana, Kari Kuulasmaa, Susana Sans, Michael H Olsen, On behalf of the MORGAM Project

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Abstract

This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project with baseline between 1982 and 1997, 68 551 subjects aged 19 to 78 years, without cardiovascular disease and not receiving antihypertensive treatment, were included. During a mean of 13.2 years of follow-up, stroke incidence was 2.8%. Stroke risk was analyzed using hazard ratios per 10-mm Hg/5-mm Hg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, DBP was analyzed separately for DBP =71 mm Hg and DBP

Original language	English
Pages (from-to)	1117-1123
Number of pages	7
Journal	Hypertension
Volume	60
Issue number	5
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.112.201400
Publication status	Published - 24 Sep 2012

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/HYPERTENSIONAHA.112.201400

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Vishram, J. K. K., Borglykke, A., Andreasen, A. H., Jeppesen, J., Ibsen, H., Jørgensen, T., Broda, G., Palmieri, L., Giampaoli, S., Donfrancesco, C., Kee, F., Mancia, G., Cesana, G., Kuulasmaa, K., Sans, S., Olsen, M. H., & On behalf of the MORGAM Project (2012). Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project. Hypertension, 60(5), 1117-1123. https://doi.org/10.1161/HYPERTENSIONAHA.112.201400

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title = "Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project",

abstract = "This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project with baseline between 1982 and 1997, 68 551 subjects aged 19 to 78 years, without cardiovascular disease and not receiving antihypertensive treatment, were included. During a mean of 13.2 years of follow-up, stroke incidence was 2.8%. Stroke risk was analyzed using hazard ratios per 10-mm Hg/5-mm Hg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, DBP was analyzed separately for DBP =71 mm Hg and DBP ",

author = "Vishram, {Julie K K} and Anders Borglykke and Andreasen, {Anne H} and J{\o}rgen Jeppesen and Hans Ibsen and Torben J{\o}rgensen and Grazyna Broda and Luigi Palmieri and Simona Giampaoli and Chiara Donfrancesco and Frank Kee and Giuseppe Mancia and Giancarlo Cesana and Kari Kuulasmaa and Susana Sans and Olsen, {Michael H} and {On behalf of the MORGAM Project}",

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doi = "10.1161/HYPERTENSIONAHA.112.201400",

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Vishram, JKK, Borglykke, A, Andreasen, AH, Jeppesen, J, Ibsen, H, Jørgensen, T, Broda, G, Palmieri, L, Giampaoli, S, Donfrancesco, C, Kee, F, Mancia, G, Cesana, G, Kuulasmaa, K, Sans, S, Olsen, MH & On behalf of the MORGAM Project 2012, 'Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project', Hypertension, vol. 60, no. 5, pp. 1117-1123. https://doi.org/10.1161/HYPERTENSIONAHA.112.201400

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T1 - Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk

T2 - The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project

AU - Vishram, Julie K K

AU - Borglykke, Anders

AU - Andreasen, Anne H

AU - Jeppesen, Jørgen

AU - Ibsen, Hans

AU - Jørgensen, Torben

AU - Broda, Grazyna

AU - Palmieri, Luigi

AU - Giampaoli, Simona

AU - Donfrancesco, Chiara

AU - Kee, Frank

AU - Mancia, Giuseppe

AU - Cesana, Giancarlo

AU - Kuulasmaa, Kari

AU - Sans, Susana

AU - Olsen, Michael H

AU - On behalf of the MORGAM Project

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AB - This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project with baseline between 1982 and 1997, 68 551 subjects aged 19 to 78 years, without cardiovascular disease and not receiving antihypertensive treatment, were included. During a mean of 13.2 years of follow-up, stroke incidence was 2.8%. Stroke risk was analyzed using hazard ratios per 10-mm Hg/5-mm Hg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, DBP was analyzed separately for DBP =71 mm Hg and DBP

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JO - Hypertension

JF - Hypertension

SN - 0194-911X

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ER -

Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project

Abstract

ASJC Scopus subject areas

UN SDGs

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