IMPACT OF DNA REPAIR, FOLATE AND GLUTATHIONE GENE POLYMORPHISMS ON RISK OF NON-SMALL CELL LUNG CANCER

Cristina Perez Ramirez, Maria Luisa Canadas Garre, Ahmed Alnatsha, Eduardo Villar, Juan Ramon Delgado, Miguel Angel Calleja Hernandez, María J. Faus-Dáder

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Abstract

Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading
cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC.
No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.
Original languageEnglish
JournalPathology, research and practice
Early online date21 Nov 2017
DOIs
Publication statusEarly online date - 21 Nov 2017

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