Impact of parenteral microemulsion on healthcare therapeutics

The injectable formulations for controlled release actions play a major role in different indications. Several approaches have been implemented to achieve parenteral delivery of drugs, especially hydrophobic drugs, by using co-solvents and novel carriers, such as liposomes and cyclodextrin-based encapsulation, to make them effective tools. However, there are still a few limitations, including scale-up issues and validation failure. Other major reasons for the limited use of such formulations are incompatibility for drug and excipient processes and very few reliable polymer options available for effective drug delivery. Parenteral microemulsions are one of the better options to address these issues, providing several advantages over other drug delivery systems, including ease of formation, effective solubilization power, and self-preservation ability for the formulation. Several researchers have demonstrated microemulsion impacts on in vitro drug release, which makes it a perfect tool for optimization of parameters related to pharmacokinetic and pharmacodynamic sectors. Such approaches are helping to extend the drug residence time, which further results in more benefits for selected drug candidates.