Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

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Abstract

The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.
Original languageEnglish
Article number1379
Number of pages24
JournalPolymers
Volume10
Issue number12
DOIs
Publication statusPublished - 12 Dec 2018

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