IMRT for image-guided single vocal cord irradiation

Sarah O S Osman, Eleftheria Astreinidou, Hans C J de Boer, Fatma Keskin-Cambay, Sebastiaan Breedveld, Peter Voet, Abrahim Al-Mamgani, Ben J M Heijmen, Peter C Levendag

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

PURPOSE: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques.

METHODS AND MATERIALS: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions.

RESULTS: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk.

CONCLUSIONS: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.

Original languageEnglish
Pages (from-to)989-97
Number of pages9
JournalInternational journal of radiation oncology, biology, physics
Volume82
Issue number2
DOIs
Publication statusPublished - 01 Feb 2012

Fingerprint

vocal cords
Intensity-Modulated Radiotherapy
Vocal Cords
radiation therapy
irradiation
dosage
Organs at Risk
organs
planning
Monaco
Laryngeal Muscles
spinal cord
photon beams
Deglutition
arteries
muscles
Photons
Carotid Arteries
Tongue
Prescriptions

Bibliographical note

Copyright © 2012 Elsevier Inc. All rights reserved.

Keywords

  • Algorithms
  • Arytenoid Cartilage
  • Dose Fractionation
  • Humans
  • Laryngeal Muscles
  • Laryngeal Neoplasms
  • Monte Carlo Method
  • Organs at Risk
  • Pharyngeal Muscles
  • Radiation Injuries
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy, Image-Guided
  • Radiotherapy, Intensity-Modulated
  • Tumor Burden
  • Vocal Cords

Cite this

Osman, Sarah O S ; Astreinidou, Eleftheria ; de Boer, Hans C J ; Keskin-Cambay, Fatma ; Breedveld, Sebastiaan ; Voet, Peter ; Al-Mamgani, Abrahim ; Heijmen, Ben J M ; Levendag, Peter C. / IMRT for image-guided single vocal cord irradiation. In: International journal of radiation oncology, biology, physics. 2012 ; Vol. 82, No. 2. pp. 989-97.
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abstract = "PURPOSE: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques.METHODS AND MATERIALS: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions.RESULTS: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk.CONCLUSIONS: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.",
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author = "Osman, {Sarah O S} and Eleftheria Astreinidou and {de Boer}, {Hans C J} and Fatma Keskin-Cambay and Sebastiaan Breedveld and Peter Voet and Abrahim Al-Mamgani and Heijmen, {Ben J M} and Levendag, {Peter C}",
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Osman, SOS, Astreinidou, E, de Boer, HCJ, Keskin-Cambay, F, Breedveld, S, Voet, P, Al-Mamgani, A, Heijmen, BJM & Levendag, PC 2012, 'IMRT for image-guided single vocal cord irradiation', International journal of radiation oncology, biology, physics, vol. 82, no. 2, pp. 989-97. https://doi.org/10.1016/j.ijrobp.2010.12.022, https://doi.org/10.1016/j.ijrobp.2010.12.022

IMRT for image-guided single vocal cord irradiation. / Osman, Sarah O S; Astreinidou, Eleftheria; de Boer, Hans C J; Keskin-Cambay, Fatma; Breedveld, Sebastiaan; Voet, Peter; Al-Mamgani, Abrahim; Heijmen, Ben J M; Levendag, Peter C.

In: International journal of radiation oncology, biology, physics, Vol. 82, No. 2, 01.02.2012, p. 989-97.

Research output: Contribution to journalArticle

TY - JOUR

T1 - IMRT for image-guided single vocal cord irradiation

AU - Osman, Sarah O S

AU - Astreinidou, Eleftheria

AU - de Boer, Hans C J

AU - Keskin-Cambay, Fatma

AU - Breedveld, Sebastiaan

AU - Voet, Peter

AU - Al-Mamgani, Abrahim

AU - Heijmen, Ben J M

AU - Levendag, Peter C

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - PURPOSE: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques.METHODS AND MATERIALS: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions.RESULTS: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk.CONCLUSIONS: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.

AB - PURPOSE: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques.METHODS AND MATERIALS: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions.RESULTS: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk.CONCLUSIONS: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.

KW - Algorithms

KW - Arytenoid Cartilage

KW - Dose Fractionation

KW - Humans

KW - Laryngeal Muscles

KW - Laryngeal Neoplasms

KW - Monte Carlo Method

KW - Organs at Risk

KW - Pharyngeal Muscles

KW - Radiation Injuries

KW - Radiotherapy Planning, Computer-Assisted

KW - Radiotherapy, Image-Guided

KW - Radiotherapy, Intensity-Modulated

KW - Tumor Burden

KW - Vocal Cords

U2 - 10.1016/j.ijrobp.2010.12.022

DO - 10.1016/j.ijrobp.2010.12.022

M3 - Article

C2 - 21300449

VL - 82

SP - 989

EP - 997

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 2

ER -