Abstract
Benzimidazole is widely regarded as an important pharmacophore within the field of cancer research owing to its versatile scaffold that could be derivatised to provide a range of mechanisms of action against tumour progression. Facile synthetic strategies based on the bicyclic fused ring have led to potential and ongoing developments of target-specific and highly-effective anticancer agents. Such a promising central structure, however, inherits poor aqueous solubility from one of the parent reagents, benzene, limiting the derivatives’ therapeutic effectiveness and stalling their development progress. In the current study, we explored the potential of forming a eutectic complex between a benzimidazole derivative drug, albendazole (ABZ), and a highly soluble guest molecule, maleic acid (MA), as a solubility enhancement strategy. The said eutectic system was formed in-situ within polymeric formulation matrices during hot-melt extrusion (HME) processing.
Original language | English |
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Publication status | Published - 25 Jul 2021 |
Event | 2021 Controlled Release Society (CRS) Virtual Annual Meeting - Virtual Duration: 25 Jul 2021 → 29 Jul 2021 https://2021.controlledreleasesociety.org/ |
Conference
Conference | 2021 Controlled Release Society (CRS) Virtual Annual Meeting |
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Period | 25/07/2021 → 29/07/2021 |
Internet address |